Abstract
Epitope-specific CD8+ T lymphocytes may play an important role in controlling human immunodeficiency virus (HIV)/simian immunodeficiency virus replication. Unfortunately, standard cellular assays do not measure the antiviral efficacy (the ability to suppress virus replication) of CD8 + T lymphocytes. Certain epitope-specific CD8+ T lymphocytes may be better than others at suppressing viral replication. We compared the antiviral efficacy of two immunodominant CD8+ T lymphocyte responses-Tat28-35SL8 and Gag181-189CM9-by using a functional in vitro assay. Viral suppression by Tat-specific CD8 + T lymphocytes was consistently greater than that of Gag-specific CD8+ T lymphocytes. Such differences in antigen-specific CD8 +-T-Iymphocyte efficacy may be important for selecting CD8 + T lymphocyte epitopes for inclusion in future HIV vaccines.
| Original language | English |
|---|---|
| Pages (from-to) | 14986-14991 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 79 |
| Issue number | 23 |
| DOIs | |
| State | Published - Dec 1 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Tat28-35SL8-specific CD8+ T lymphocytes are more effective than Gag181-189CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay. / Loffredo, John T.; Rakasz, Eva G.; Giraldo, Juan Pablo; Spencer, Sean P.; Grafton, Kelly K.; Martin, Sarah R.; Napoé, Gnankang; Yant, Levi J.; Wilson, Nancy A.; Watkins, David.
In: Journal of Virology, Vol. 79, No. 23, 01.12.2005, p. 14986-14991.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tat28-35SL8-specific CD8+ T lymphocytes are more effective than Gag181-189CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay
AU - Loffredo, John T.
AU - Rakasz, Eva G.
AU - Giraldo, Juan Pablo
AU - Spencer, Sean P.
AU - Grafton, Kelly K.
AU - Martin, Sarah R.
AU - Napoé, Gnankang
AU - Yant, Levi J.
AU - Wilson, Nancy A.
AU - Watkins, David
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Epitope-specific CD8+ T lymphocytes may play an important role in controlling human immunodeficiency virus (HIV)/simian immunodeficiency virus replication. Unfortunately, standard cellular assays do not measure the antiviral efficacy (the ability to suppress virus replication) of CD8 + T lymphocytes. Certain epitope-specific CD8+ T lymphocytes may be better than others at suppressing viral replication. We compared the antiviral efficacy of two immunodominant CD8+ T lymphocyte responses-Tat28-35SL8 and Gag181-189CM9-by using a functional in vitro assay. Viral suppression by Tat-specific CD8 + T lymphocytes was consistently greater than that of Gag-specific CD8+ T lymphocytes. Such differences in antigen-specific CD8 +-T-Iymphocyte efficacy may be important for selecting CD8 + T lymphocyte epitopes for inclusion in future HIV vaccines.
AB - Epitope-specific CD8+ T lymphocytes may play an important role in controlling human immunodeficiency virus (HIV)/simian immunodeficiency virus replication. Unfortunately, standard cellular assays do not measure the antiviral efficacy (the ability to suppress virus replication) of CD8 + T lymphocytes. Certain epitope-specific CD8+ T lymphocytes may be better than others at suppressing viral replication. We compared the antiviral efficacy of two immunodominant CD8+ T lymphocyte responses-Tat28-35SL8 and Gag181-189CM9-by using a functional in vitro assay. Viral suppression by Tat-specific CD8 + T lymphocytes was consistently greater than that of Gag-specific CD8+ T lymphocytes. Such differences in antigen-specific CD8 +-T-Iymphocyte efficacy may be important for selecting CD8 + T lymphocyte epitopes for inclusion in future HIV vaccines.
UR - http://www.scopus.com/inward/record.url?scp=27744525304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744525304&partnerID=8YFLogxK
U2 - 10.1128/JVI.79.23.14986-14991.2005
DO - 10.1128/JVI.79.23.14986-14991.2005
M3 - Article
VL - 79
SP - 14986
EP - 14991
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 23
ER -