Tat28-35SL8-specific CD8+ T lymphocytes are more effective than Gag181-189CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay

John T. Loffredo, Eva G. Rakasz, Juan Pablo Giraldo, Sean P. Spencer, Kelly K. Grafton, Sarah R. Martin, Gnankang Napoé, Levi J. Yant, Nancy A. Wilson, David I. Watkins

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Epitope-specific CD8+ T lymphocytes may play an important role in controlling human immunodeficiency virus (HIV)/simian immunodeficiency virus replication. Unfortunately, standard cellular assays do not measure the antiviral efficacy (the ability to suppress virus replication) of CD8 + T lymphocytes. Certain epitope-specific CD8+ T lymphocytes may be better than others at suppressing viral replication. We compared the antiviral efficacy of two immunodominant CD8+ T lymphocyte responses-Tat28-35SL8 and Gag181-189CM9-by using a functional in vitro assay. Viral suppression by Tat-specific CD8 + T lymphocytes was consistently greater than that of Gag-specific CD8+ T lymphocytes. Such differences in antigen-specific CD8 +-T-Iymphocyte efficacy may be important for selecting CD8 + T lymphocyte epitopes for inclusion in future HIV vaccines.

Original languageEnglish (US)
Pages (from-to)14986-14991
Number of pages6
JournalJournal of virology
Volume79
Issue number23
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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