Abstract
Epitope-specific CD8+ T lymphocytes may play an important role in controlling human immunodeficiency virus (HIV)/simian immunodeficiency virus replication. Unfortunately, standard cellular assays do not measure the antiviral efficacy (the ability to suppress virus replication) of CD8 + T lymphocytes. Certain epitope-specific CD8+ T lymphocytes may be better than others at suppressing viral replication. We compared the antiviral efficacy of two immunodominant CD8+ T lymphocyte responses-Tat28-35SL8 and Gag181-189CM9-by using a functional in vitro assay. Viral suppression by Tat-specific CD8 + T lymphocytes was consistently greater than that of Gag-specific CD8+ T lymphocytes. Such differences in antigen-specific CD8 +-T-Iymphocyte efficacy may be important for selecting CD8 + T lymphocyte epitopes for inclusion in future HIV vaccines.
Original language | English (US) |
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Pages (from-to) | 14986-14991 |
Number of pages | 6 |
Journal | Journal of virology |
Volume | 79 |
Issue number | 23 |
DOIs | |
State | Published - Dec 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology