Abstract
The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.
| Original language | English |
|---|---|
| Pages (from-to) | 4108-4112 |
| Number of pages | 5 |
| Journal | Journal of Virology |
| Volume | 76 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 6 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. / Allen, Todd M.; Mortara, Lorenzo; Mothé, Bianca R.; Liebl, Max; Jing, Peicheng; Calore, Briana; Piekarczyk, Marian; Ruddersdorf, Richard; O'Connor, David H.; Wang, X.; Wang, Chenxi; Allison, David B.; Altman, John D.; Sette, Alessandro; Desrosiers, Ronald Charles; Sutter, Gerd; Watkins, David.
In: Journal of Virology, Vol. 76, No. 8, 06.04.2002, p. 4108-4112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication
AU - Allen, Todd M.
AU - Mortara, Lorenzo
AU - Mothé, Bianca R.
AU - Liebl, Max
AU - Jing, Peicheng
AU - Calore, Briana
AU - Piekarczyk, Marian
AU - Ruddersdorf, Richard
AU - O'Connor, David H.
AU - Wang, X.
AU - Wang, Chenxi
AU - Allison, David B.
AU - Altman, John D.
AU - Sette, Alessandro
AU - Desrosiers, Ronald Charles
AU - Sutter, Gerd
AU - Watkins, David
PY - 2002/4/6
Y1 - 2002/4/6
N2 - The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.
AB - The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.
UR - http://www.scopus.com/inward/record.url?scp=0036194524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036194524&partnerID=8YFLogxK
U2 - 10.1128/JVI.76.8.4108-4112.2002
DO - 10.1128/JVI.76.8.4108-4112.2002
M3 - Article
VL - 76
SP - 4108
EP - 4112
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 8
ER -