Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

Todd M. Allen, Lorenzo Mortara, Bianca R. Mothé, Max Liebl, Peicheng Jing, Briana Calore, Marian Piekarczyk, Richard Ruddersdorf, David H. O'Connor, X. Wang, Chenxi Wang, David B. Allison, John D. Altman, Alessandro Sette, Ronald Charles Desrosiers, Gerd Sutter, David Watkins

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

Original languageEnglish
Pages (from-to)4108-4112
Number of pages5
JournalJournal of Virology
Volume76
Issue number8
DOIs
StatePublished - Apr 6 2002
Externally publishedYes

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
cytotoxic T-lymphocytes
Macaca
Cytotoxic T-Lymphocytes
Virus Replication
virus replication
Vaccines
vaccines
Human Immunodeficiency Virus Proteins
Vaccinia virus
Human immunodeficiency virus
regulatory proteins
DNA

ASJC Scopus subject areas

  • Immunology

Cite this

Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. / Allen, Todd M.; Mortara, Lorenzo; Mothé, Bianca R.; Liebl, Max; Jing, Peicheng; Calore, Briana; Piekarczyk, Marian; Ruddersdorf, Richard; O'Connor, David H.; Wang, X.; Wang, Chenxi; Allison, David B.; Altman, John D.; Sette, Alessandro; Desrosiers, Ronald Charles; Sutter, Gerd; Watkins, David.

In: Journal of Virology, Vol. 76, No. 8, 06.04.2002, p. 4108-4112.

Research output: Contribution to journalArticle

Allen, TM, Mortara, L, Mothé, BR, Liebl, M, Jing, P, Calore, B, Piekarczyk, M, Ruddersdorf, R, O'Connor, DH, Wang, X, Wang, C, Allison, DB, Altman, JD, Sette, A, Desrosiers, RC, Sutter, G & Watkins, D 2002, 'Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication', Journal of Virology, vol. 76, no. 8, pp. 4108-4112. https://doi.org/10.1128/JVI.76.8.4108-4112.2002
Allen, Todd M. ; Mortara, Lorenzo ; Mothé, Bianca R. ; Liebl, Max ; Jing, Peicheng ; Calore, Briana ; Piekarczyk, Marian ; Ruddersdorf, Richard ; O'Connor, David H. ; Wang, X. ; Wang, Chenxi ; Allison, David B. ; Altman, John D. ; Sette, Alessandro ; Desrosiers, Ronald Charles ; Sutter, Gerd ; Watkins, David. / Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. In: Journal of Virology. 2002 ; Vol. 76, No. 8. pp. 4108-4112.
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