Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

Todd M. Allen; Lorenzo Mortara; Bianca R. Mothé; Max Liebl; Peicheng Jing; Briana Calore; Marian Piekarczyk; Richard Ruddersdorf; David H. O'Connor; X. Wang; Chenxi Wang; David B. Allison; John D. Altman; Alessandro Sette; Ronald C. Desrosiers; Gerd Sutter; David I. Watkins

doi:10.1128/JVI.76.8.4108-4112.2002

Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

Todd M. Allen, Lorenzo Mortara, Bianca R. Mothé, Max Liebl, Peicheng Jing, Briana Calore, Marian Piekarczyk, Richard Ruddersdorf, David H. O'Connor, X. Wang, Chenxi Wang, David B. Allison, John D. Altman, Alessandro Sette, Ronald C. Desrosiers, Gerd Sutter, David I. Watkins

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

Original language	English (US)
Pages (from-to)	4108-4112
Number of pages	5
Journal	Journal of virology
Volume	76
Issue number	8
DOIs	https://doi.org/10.1128/JVI.76.8.4108-4112.2002
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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Allen, T. M., Mortara, L., Mothé, B. R., Liebl, M., Jing, P., Calore, B., Piekarczyk, M., Ruddersdorf, R., O'Connor, D. H., Wang, X., Wang, C., Allison, D. B., Altman, J. D., Sette, A., Desrosiers, R. C., Sutter, G., & Watkins, D. I. (2002). Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. Journal of virology, 76(8), 4108-4112. https://doi.org/10.1128/JVI.76.8.4108-4112.2002

Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. / Allen, Todd M.; Mortara, Lorenzo; Mothé, Bianca R.; Liebl, Max; Jing, Peicheng; Calore, Briana; Piekarczyk, Marian; Ruddersdorf, Richard; O'Connor, David H.; Wang, X.; Wang, Chenxi; Allison, David B.; Altman, John D.; Sette, Alessandro; Desrosiers, Ronald C.; Sutter, Gerd; Watkins, David I.

In: Journal of virology, Vol. 76, No. 8, 2002, p. 4108-4112.

Research output: Contribution to journal › Article › peer-review

Allen, TM, Mortara, L, Mothé, BR, Liebl, M, Jing, P, Calore, B, Piekarczyk, M, Ruddersdorf, R, O'Connor, DH, Wang, X, Wang, C, Allison, DB, Altman, JD, Sette, A, Desrosiers, RC, Sutter, G & Watkins, DI 2002, 'Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication', Journal of virology, vol. 76, no. 8, pp. 4108-4112. https://doi.org/10.1128/JVI.76.8.4108-4112.2002

Allen, Todd M. ; Mortara, Lorenzo ; Mothé, Bianca R. ; Liebl, Max ; Jing, Peicheng ; Calore, Briana ; Piekarczyk, Marian ; Ruddersdorf, Richard ; O'Connor, David H. ; Wang, X. ; Wang, Chenxi ; Allison, David B. ; Altman, John D. ; Sette, Alessandro ; Desrosiers, Ronald C. ; Sutter, Gerd ; Watkins, David I. / Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. In: Journal of virology. 2002 ; Vol. 76, No. 8. pp. 4108-4112.

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abstract = "The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.",

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AU - Wang, X.

AU - Wang, Chenxi

AU - Allison, David B.

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AU - Sette, Alessandro

AU - Desrosiers, Ronald C.

AU - Sutter, Gerd

AU - Watkins, David I.

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Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

Abstract

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