Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

Todd M. Allen, Lorenzo Mortara, Bianca R. Mothé, Max Liebl, Peicheng Jing, Briana Calore, Marian Piekarczyk, Richard Ruddersdorf, David H. O'Connor, X. Wang, Chenxi Wang, David B. Allison, John D. Altman, Alessandro Sette, Ronald C. Desrosiers, Gerd Sutter, David I. Watkins

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

Original languageEnglish (US)
Pages (from-to)4108-4112
Number of pages5
JournalJournal of virology
Volume76
Issue number8
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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