Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary vimamia

Todd M. Allen, David H. O'Connor, Peicheng Jing, John L. Dzuris, Bianca R. Mothé, Thorsten U. Vogel, Ed Dunphy, Max E. Liebl, Carol Emerson, Nancy Wilson, Kevin J. Kunstman, Xiaochi Wang, David B. Allison, Austin L. Hughes, Ronald Charles Desrosiers, John D. Altman, Steven M. Wollnsky, Alessandro Sette, David Watkins

Research output: Contribution to journalArticle

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Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections are characterized by early peaks of viraemia that decline as strong cellular immune responses develop1,2. Although it has been shown that virus-specific CD8-positive cytotoxic T lymphocytes (CTLs) exert selective pressure during HIV and SIV infection3-11, the data have been controversial12,13. Here we show that Tat-specific CD8-positive T-lymphocyte responses select for new viral escape variants during the acute phase of infection. We sequenced the entire virus immediately after the acute phase, and found that amino-acid replacements accumulated primarily in Tat CTL epitopes. This implies that Tat-specific CTLs may be significantly involved in controlling wild-type virus replication, and suggests that responses against viral proteins that are expressed early during the viral life cycle might be attractive targets for HIV vaccine development.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalNature
Volume407
Issue number6802
DOIs
StatePublished - Sep 21 2000
Externally publishedYes

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Simian Immunodeficiency Virus
Cytotoxic T-Lymphocytes
CD8-Positive T-Lymphocytes
HIV
Viruses
T-Lymphocyte Epitopes
Viremia
Viral Proteins
Virus Diseases
Virus Replication
Life Cycle Stages
Cellular Immunity
Vaccines
Amino Acids
Infection

ASJC Scopus subject areas

  • General

Cite this

Allen, T. M., O'Connor, D. H., Jing, P., Dzuris, J. L., Mothé, B. R., Vogel, T. U., ... Watkins, D. (2000). Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary vimamia. Nature, 407(6802), 386-390. https://doi.org/10.1038/35030124

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary vimamia. / Allen, Todd M.; O'Connor, David H.; Jing, Peicheng; Dzuris, John L.; Mothé, Bianca R.; Vogel, Thorsten U.; Dunphy, Ed; Liebl, Max E.; Emerson, Carol; Wilson, Nancy; Kunstman, Kevin J.; Wang, Xiaochi; Allison, David B.; Hughes, Austin L.; Desrosiers, Ronald Charles; Altman, John D.; Wollnsky, Steven M.; Sette, Alessandro; Watkins, David.

In: Nature, Vol. 407, No. 6802, 21.09.2000, p. 386-390.

Research output: Contribution to journalArticle

Allen, TM, O'Connor, DH, Jing, P, Dzuris, JL, Mothé, BR, Vogel, TU, Dunphy, E, Liebl, ME, Emerson, C, Wilson, N, Kunstman, KJ, Wang, X, Allison, DB, Hughes, AL, Desrosiers, RC, Altman, JD, Wollnsky, SM, Sette, A & Watkins, D 2000, 'Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary vimamia', Nature, vol. 407, no. 6802, pp. 386-390. https://doi.org/10.1038/35030124
Allen TM, O'Connor DH, Jing P, Dzuris JL, Mothé BR, Vogel TU et al. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary vimamia. Nature. 2000 Sep 21;407(6802):386-390. https://doi.org/10.1038/35030124
Allen, Todd M. ; O'Connor, David H. ; Jing, Peicheng ; Dzuris, John L. ; Mothé, Bianca R. ; Vogel, Thorsten U. ; Dunphy, Ed ; Liebl, Max E. ; Emerson, Carol ; Wilson, Nancy ; Kunstman, Kevin J. ; Wang, Xiaochi ; Allison, David B. ; Hughes, Austin L. ; Desrosiers, Ronald Charles ; Altman, John D. ; Wollnsky, Steven M. ; Sette, Alessandro ; Watkins, David. / Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary vimamia. In: Nature. 2000 ; Vol. 407, No. 6802. pp. 386-390.
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