Taste preference synergy between glutamate receptor agonists and inosine monophosphate in rats

E. R. Delay, A. J. Beaver, K. A. Wagner, J. R. Stapleton, J. O. Harbaugh, K. D. Catron, Stephen D Roper

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Monosodium glutamate (MSG) elicits a taste called umami and interacts synergistically with nucleotide monophosphates such as 5'-inosine monophosphate (IMP) to potentiate this taste intensity. Indeed, the synergistic interaction of nucleotide monophosphates and MSG is a hallmark of umami. We examined interactions between MSG and other taste stimuli, including IMP, by measuring the lick rates of non-deprived rats during 30 s trials. To control for non-linear psychophysical functions, the concentration of one taste stimulus in a binary mixture was systematically increased while the concentration of the second taste stimulus was decreased (stimulus substitution method). Synergy between two stimuli was detected if the lick rate for a binary mixture exceeded that expected from the sum of the lick rates for each stimulus alone. In initial experiments, taste synergy was observed when rats were presented with mixtures of MSG and IMP but not with mixtures of MSG and sucrose. In subsequent experiments, glutamate receptor agonists other than MSG were presented with IMP to test for taste synergy. No evidence of synergy was seen when rats were presented with mixtures of IMP and kainic acid or IMP and N-methyl-D-aspartate. However, taste synergy between IMP and L-AP4, a potent agonist at mGluR4 receptors, was observed. These results suggest that a metabotropic glutamate receptor similar to mGluR4 may be involved in the taste synergy that characterizes umami.

Original languageEnglish
Pages (from-to)507-515
Number of pages9
JournalChemical Senses
Volume25
Issue number5
StatePublished - Nov 2 2000

Fingerprint

inosine monophosphate
Excitatory Amino Acid Agonists
Inosine Monophosphate
Glutamate Receptors
food choices
agonists
monosodium glutamate
Sodium Glutamate
rats
umami
Nucleotides
nucleotides
glutamate receptors
Metabotropic Glutamate Receptors
Kainic Acid
N-Methylaspartate
aspartic acid
Sucrose
sucrose

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Neuroscience(all)
  • Physiology
  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Delay, E. R., Beaver, A. J., Wagner, K. A., Stapleton, J. R., Harbaugh, J. O., Catron, K. D., & Roper, S. D. (2000). Taste preference synergy between glutamate receptor agonists and inosine monophosphate in rats. Chemical Senses, 25(5), 507-515.

Taste preference synergy between glutamate receptor agonists and inosine monophosphate in rats. / Delay, E. R.; Beaver, A. J.; Wagner, K. A.; Stapleton, J. R.; Harbaugh, J. O.; Catron, K. D.; Roper, Stephen D.

In: Chemical Senses, Vol. 25, No. 5, 02.11.2000, p. 507-515.

Research output: Contribution to journalArticle

Delay, ER, Beaver, AJ, Wagner, KA, Stapleton, JR, Harbaugh, JO, Catron, KD & Roper, SD 2000, 'Taste preference synergy between glutamate receptor agonists and inosine monophosphate in rats', Chemical Senses, vol. 25, no. 5, pp. 507-515.
Delay ER, Beaver AJ, Wagner KA, Stapleton JR, Harbaugh JO, Catron KD et al. Taste preference synergy between glutamate receptor agonists and inosine monophosphate in rats. Chemical Senses. 2000 Nov 2;25(5):507-515.
Delay, E. R. ; Beaver, A. J. ; Wagner, K. A. ; Stapleton, J. R. ; Harbaugh, J. O. ; Catron, K. D. ; Roper, Stephen D. / Taste preference synergy between glutamate receptor agonists and inosine monophosphate in rats. In: Chemical Senses. 2000 ; Vol. 25, No. 5. pp. 507-515.
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