Targets for molecular intervention in multistep pulmonary carcinogenesis

David S. Schrump, Dao M. Nguyen

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Lung cancers are a leading cause of mortality worldwide, and most of these neoplasms are directly attributable to tobacco abuse. Recent studies have begun to elucidate molecular mechanisms of multistep aero-digestive tract carcinogenesis, revealing novel targets for intervention in lung cancers and their precursor lesions. This review summarizes the molecular biology of lung cancers in relation to the prognosis and treatment of patients with these neoplasms.

Original languageEnglish (US)
Pages (from-to)174-183
Number of pages10
JournalWorld Journal of Surgery
Issue number2
StatePublished - Apr 26 2001
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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