Targeting the therapeutic effects of exercise on redox-sensitive mechanisms in the vascular endothelium during tumor progression

Gretchen Wolff, Michal Toborek

Research output: Contribution to journalReview article

3 Scopus citations


The American Cancer Society estimated 1.5 million new cancer cases in the United States in 2012. Although the exact number is not known, it is estimated that brain metastases occur in 20-40% of cancer patients (39). Owing to the complexity of development and the variation in tumor etiology, therapy options have been limited for a number of cancers, whereas progressive treatments have been successful for some malignancies. Combining treatment strategies has shown potential to increase positive outcomes; however, cancer remains a formidable diagnosis with no true cure. Many researchers have focused on alternative forms of cancer prevention or treatment to slow cancer progression. Studies have shown that with moderate, regular exercise signaling pathways associated with increased antioxidant activity and cellular repair are upregulated in vascular tissue; however, the physiological mechanisms are poorly understood. The purpose of this review is to examine the current literature to better understand the impact of exercise on cancer progression and tumor metastasis and discuss potential redox-related signaling in the vasculature that may be involved.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalIUBMB life
Issue number7
StatePublished - Jul 1 2013



  • brain microvasculature
  • cancer
  • exercise
  • metastasis
  • reactive oxygen species
  • tight junction

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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