Targeting the host inflammatory response in traumatic spinal cord injury

John R Bethea, W. Dalton Dietrich

Research output: Contribution to journalReview article

178 Scopus citations

Abstract

Both acute and chronic inflammatory processes have been shown to influence outcome in experimental models of spinal cord injury. Although early inflammatory responses may participate in secondary injury processes, more delayed inflammatory events may be reparative. Therapeutic strategies that target these events are currently based on experimental findings that have clarified the cellular and molecular processes involved in the inflammatory response to injury. An increasing body of literature supports the hypothesis that acute inflammatory events are attenuated by therapeutic hypothermia and other anti-inflammatory strategies, whereas immune neuroprotection and axonal regeneration can be achieved by transfer of activated T cells or by treatment with therapeutic vaccines. These data are summarized in the present review.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalCurrent Opinion in Neurology
Volume15
Issue number3
DOIs
StatePublished - Jun 17 2002

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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