Targeting gastrin releasing peptide receptors: New options for the therapy and diagnosis of cancer

Florian Hohla, Andrew V. Schally

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Gastrin-releasing peptide (GRP), the mammalian bombesin (BN), appears to be involved in the growth of several neoplasms. BN/GRP receptors (BN/GRP-Rs) are expressed in a variety of cancer cells and have limited distribution in normal human tissue. Thus inhibition of BN/GRP-Rs represents an attractive target for pharmacological treatment of some human malignancies. This review will focus on intracellular signaling pathways which have been characterized to mediate BN/GRP-dependent receptor biological effects as well as on various approaches to target BN/GRP-Rs for therapeutic and diagnostic interventions in human malignancies.

Original languageEnglish (US)
Pages (from-to)1738-1741
Number of pages4
JournalCell Cycle
Volume9
Issue number9
DOIs
StatePublished - May 1 2010

Keywords

  • Bombesin/gastrin releasing peptide analogs
  • Bombesin/gastrin releasing peptide receptors
  • Cytotoxic analogs
  • Targeted therapy

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

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