Targeting gastrin releasing peptide receptors

New options for the therapy and diagnosis of cancer

Florian Hohla, Andrew V Schally

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Gastrin-releasing peptide (GRP), the mammalian bombesin (BN), appears to be involved in the growth of several neoplasms. BN/GRP receptors (BN/GRP-Rs) are expressed in a variety of cancer cells and have limited distribution in normal human tissue. Thus inhibition of BN/GRP-Rs represents an attractive target for pharmacological treatment of some human malignancies. This review will focus on intracellular signaling pathways which have been characterized to mediate BN/GRP-dependent receptor biological effects as well as on various approaches to target BN/GRP-Rs for therapeutic and diagnostic interventions in human malignancies.

Original languageEnglish
Pages (from-to)1738-1741
Number of pages4
JournalCell Cycle
Volume9
Issue number9
DOIs
StatePublished - May 1 2010

Fingerprint

Bombesin Receptors
Bombesin
Gastrin-Releasing Peptide
Neoplasms
Therapeutics
Normal Distribution
Pharmacology
Growth

Keywords

  • Bombesin/gastrin releasing peptide analogs
  • Bombesin/gastrin releasing peptide receptors
  • Cytotoxic analogs
  • Targeted therapy

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Targeting gastrin releasing peptide receptors : New options for the therapy and diagnosis of cancer. / Hohla, Florian; Schally, Andrew V.

In: Cell Cycle, Vol. 9, No. 9, 01.05.2010, p. 1738-1741.

Research output: Contribution to journalArticle

@article{1979674b707c4a369bb8324f0a05631d,
title = "Targeting gastrin releasing peptide receptors: New options for the therapy and diagnosis of cancer",
abstract = "Gastrin-releasing peptide (GRP), the mammalian bombesin (BN), appears to be involved in the growth of several neoplasms. BN/GRP receptors (BN/GRP-Rs) are expressed in a variety of cancer cells and have limited distribution in normal human tissue. Thus inhibition of BN/GRP-Rs represents an attractive target for pharmacological treatment of some human malignancies. This review will focus on intracellular signaling pathways which have been characterized to mediate BN/GRP-dependent receptor biological effects as well as on various approaches to target BN/GRP-Rs for therapeutic and diagnostic interventions in human malignancies.",
keywords = "Bombesin/gastrin releasing peptide analogs, Bombesin/gastrin releasing peptide receptors, Cytotoxic analogs, Targeted therapy",
author = "Florian Hohla and Schally, {Andrew V}",
year = "2010",
month = "5",
day = "1",
doi = "10.4161/cc.9.9.11347",
language = "English",
volume = "9",
pages = "1738--1741",
journal = "Cell Cycle",
issn = "1538-4101",
publisher = "Landes Bioscience",
number = "9",

}

TY - JOUR

T1 - Targeting gastrin releasing peptide receptors

T2 - New options for the therapy and diagnosis of cancer

AU - Hohla, Florian

AU - Schally, Andrew V

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Gastrin-releasing peptide (GRP), the mammalian bombesin (BN), appears to be involved in the growth of several neoplasms. BN/GRP receptors (BN/GRP-Rs) are expressed in a variety of cancer cells and have limited distribution in normal human tissue. Thus inhibition of BN/GRP-Rs represents an attractive target for pharmacological treatment of some human malignancies. This review will focus on intracellular signaling pathways which have been characterized to mediate BN/GRP-dependent receptor biological effects as well as on various approaches to target BN/GRP-Rs for therapeutic and diagnostic interventions in human malignancies.

AB - Gastrin-releasing peptide (GRP), the mammalian bombesin (BN), appears to be involved in the growth of several neoplasms. BN/GRP receptors (BN/GRP-Rs) are expressed in a variety of cancer cells and have limited distribution in normal human tissue. Thus inhibition of BN/GRP-Rs represents an attractive target for pharmacological treatment of some human malignancies. This review will focus on intracellular signaling pathways which have been characterized to mediate BN/GRP-dependent receptor biological effects as well as on various approaches to target BN/GRP-Rs for therapeutic and diagnostic interventions in human malignancies.

KW - Bombesin/gastrin releasing peptide analogs

KW - Bombesin/gastrin releasing peptide receptors

KW - Cytotoxic analogs

KW - Targeted therapy

UR - http://www.scopus.com/inward/record.url?scp=77953555625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953555625&partnerID=8YFLogxK

U2 - 10.4161/cc.9.9.11347

DO - 10.4161/cc.9.9.11347

M3 - Article

VL - 9

SP - 1738

EP - 1741

JO - Cell Cycle

JF - Cell Cycle

SN - 1538-4101

IS - 9

ER -