Targeting Arterial Oxygen Saturation by Closed-Loop Control of Inspired Oxygen in Preterm Infants

Research output: Contribution to journalReview article

Abstract

Exposure to hyperoxemia from excessive oxygen supplementation and episodes of intermittent hypoxemia have been associated with damage to the eye, lung, and central nervous system in premature infants. The inherent respiratory instability of the premature infant combined with limited staffing or equipment resources often affect SpO2 targeting and increase exposure to extreme SpO2 levels. Multiple systems for closed loop control of inspired oxygen have been developed to improve SpO2 targeting. This article reviews the evidence provided by clinical studies evaluating the efficacy of these systems in extreme premature infants.

Original languageEnglish (US)
JournalClinics in Perinatology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Premature Infants
Oxygen
Central Nervous System
Equipment and Supplies
Lung

Keywords

  • Automatic
  • Oxygen therapy
  • Oxygenation
  • Premature infant
  • Supplemental oxygen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

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title = "Targeting Arterial Oxygen Saturation by Closed-Loop Control of Inspired Oxygen in Preterm Infants",
abstract = "Exposure to hyperoxemia from excessive oxygen supplementation and episodes of intermittent hypoxemia have been associated with damage to the eye, lung, and central nervous system in premature infants. The inherent respiratory instability of the premature infant combined with limited staffing or equipment resources often affect SpO2 targeting and increase exposure to extreme SpO2 levels. Multiple systems for closed loop control of inspired oxygen have been developed to improve SpO2 targeting. This article reviews the evidence provided by clinical studies evaluating the efficacy of these systems in extreme premature infants.",
keywords = "Automatic, Oxygen therapy, Oxygenation, Premature infant, Supplemental oxygen",
author = "Nelson Claure and Eduardo Bancalari",
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AU - Bancalari, Eduardo

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N2 - Exposure to hyperoxemia from excessive oxygen supplementation and episodes of intermittent hypoxemia have been associated with damage to the eye, lung, and central nervous system in premature infants. The inherent respiratory instability of the premature infant combined with limited staffing or equipment resources often affect SpO2 targeting and increase exposure to extreme SpO2 levels. Multiple systems for closed loop control of inspired oxygen have been developed to improve SpO2 targeting. This article reviews the evidence provided by clinical studies evaluating the efficacy of these systems in extreme premature infants.

AB - Exposure to hyperoxemia from excessive oxygen supplementation and episodes of intermittent hypoxemia have been associated with damage to the eye, lung, and central nervous system in premature infants. The inherent respiratory instability of the premature infant combined with limited staffing or equipment resources often affect SpO2 targeting and increase exposure to extreme SpO2 levels. Multiple systems for closed loop control of inspired oxygen have been developed to improve SpO2 targeting. This article reviews the evidence provided by clinical studies evaluating the efficacy of these systems in extreme premature infants.

KW - Automatic

KW - Oxygen therapy

KW - Oxygenation

KW - Premature infant

KW - Supplemental oxygen

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