Targeting angiogenesis in the treatment of hepatic metastasis

Christina M. Edwards, J. Joshua Smith, Nipun B. Merchant, Alexander A. Parikh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The liver is the most common site for the development of metastases from gastrointestinal malignancies. Although the only potentially curative option for patients with liver metastases is resection, only a minority are candidates. In order to increase the number of patients who may be candidates for resection, preoperative systemic chemotherapy and targeted therapy approaches have been utilized. Angiogenesis has been shown to be integral for the growth and metastasis of many tumor types including the development of liver metastases. The development of antiangiogenic approaches, particularly anti vascular endothelial growth factor (VEGF) therapy with bevacizumab, has shown great promise in the treatment of patients with liver metastases, particularly from colorectal cancer and to a lesser degree, neuroendocrine carcinoma. These approaches have allowed physicians to increase the number of patients that may be amenable for curative resection. As angiogenesis and VEGF have been shown to be important in liver hypertrophy and regeneration, however, the possible effects of anti-VEGF therapy on liver recovery may carry significant risks along with the potential benefits.

Original languageEnglish (US)
Title of host publicationLiver Metastasis
Subtitle of host publicationBiology and Clinical Management
EditorsPnina Brodt
Pages417-430
Number of pages14
Edition1
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

Publication series

NameCancer Metastasis - Biology and Treatment
Number1
Volume16
ISSN (Print)1568-2102

Keywords

  • Angiogenesis
  • Bevacizumab
  • Liver
  • Neoadjuvant
  • VEGF

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Edwards, C. M., Smith, J. J., Merchant, N. B., & Parikh, A. A. (2011). Targeting angiogenesis in the treatment of hepatic metastasis. In P. Brodt (Ed.), Liver Metastasis: Biology and Clinical Management (1 ed., pp. 417-430). (Cancer Metastasis - Biology and Treatment; Vol. 16, No. 1). https://doi.org/10.1007/978-94-007-0292-9_15