Tall cell papillary thyroid carcinoma metastatic to femur

Evidence for thyroid hormone synthesis within the femur

Elizabeth Lawrence, Sarah T. Lord, Yesenia Leon, Patrick J. McIntyre, Jaime Penix, Dmitry Grebenev, David L. Vesely

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 67-year old man with a 3-month history of left hip pain had a history of Graves disease, treated with 131I 20 years before admission, and papillary thyroid carcinoma, treated with cervical lymphadenopathy 9 years before admission. Removal of a 3.5- × 5-cm mass from the left femur revealed it to be a tall cell variant of papillary thyroid carcinoma. Removal of this mass resulted in his thyrotropin level increasing from 2 (presurgery) to 23 mlU/mL, whereas his thyroxine level simultaneously decreased from 5.79 (presurgery) to 2.29 μg/dL 12 days after surgery despite continuation of levothyroxine of 0.137 mg/day. On histological examination, the tall cell variant in the femur was producing abundant thyroglobulin. This first case of a metastatic papillary thyroid carcinoma in bone producing thyroid hormone to the extent that the patient became hypothyroid after removal of this metastasis illustrates that metastatic thyroid lesion(s) may produce significant amounts of thyroid hormone.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume322
Issue number2
StatePublished - Aug 27 2001

Fingerprint

Thyroid Hormones
Femur
Thyroxine
Thyroglobulin
Graves Disease
Thyrotropin
Ambulatory Surgical Procedures
Hip
Thyroid Gland
Neoplasm Metastasis
Bone and Bones
Pain
Papillary Thyroid cancer

Keywords

  • Bone metastasis
  • Tall cell papillary thyroid carcinomas

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lawrence, E., Lord, S. T., Leon, Y., McIntyre, P. J., Penix, J., Grebenev, D., & Vesely, D. L. (2001). Tall cell papillary thyroid carcinoma metastatic to femur: Evidence for thyroid hormone synthesis within the femur. American Journal of the Medical Sciences, 322(2), 103-108.

Tall cell papillary thyroid carcinoma metastatic to femur : Evidence for thyroid hormone synthesis within the femur. / Lawrence, Elizabeth; Lord, Sarah T.; Leon, Yesenia; McIntyre, Patrick J.; Penix, Jaime; Grebenev, Dmitry; Vesely, David L.

In: American Journal of the Medical Sciences, Vol. 322, No. 2, 27.08.2001, p. 103-108.

Research output: Contribution to journalArticle

Lawrence, E, Lord, ST, Leon, Y, McIntyre, PJ, Penix, J, Grebenev, D & Vesely, DL 2001, 'Tall cell papillary thyroid carcinoma metastatic to femur: Evidence for thyroid hormone synthesis within the femur', American Journal of the Medical Sciences, vol. 322, no. 2, pp. 103-108.
Lawrence, Elizabeth ; Lord, Sarah T. ; Leon, Yesenia ; McIntyre, Patrick J. ; Penix, Jaime ; Grebenev, Dmitry ; Vesely, David L. / Tall cell papillary thyroid carcinoma metastatic to femur : Evidence for thyroid hormone synthesis within the femur. In: American Journal of the Medical Sciences. 2001 ; Vol. 322, No. 2. pp. 103-108.
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