Tall cell papillary thyroid carcinoma metastatic to femur: Evidence for thyroid hormone synthesis within the femur

Elizabeth Lawrence, Sarah T. Lord, Yesenia Leon, Patrick J. McIntyre, Jaime Penix, Dmitry Grebenev, David L. Vesely

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A 67-year old man with a 3-month history of left hip pain had a history of Graves disease, treated with 131I 20 years before admission, and papillary thyroid carcinoma, treated with cervical lymphadenopathy 9 years before admission. Removal of a 3.5- × 5-cm mass from the left femur revealed it to be a tall cell variant of papillary thyroid carcinoma. Removal of this mass resulted in his thyrotropin level increasing from 2 (presurgery) to 23 mlU/mL, whereas his thyroxine level simultaneously decreased from 5.79 (presurgery) to 2.29 μg/dL 12 days after surgery despite continuation of levothyroxine of 0.137 mg/day. On histological examination, the tall cell variant in the femur was producing abundant thyroglobulin. This first case of a metastatic papillary thyroid carcinoma in bone producing thyroid hormone to the extent that the patient became hypothyroid after removal of this metastasis illustrates that metastatic thyroid lesion(s) may produce significant amounts of thyroid hormone.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume322
Issue number2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Bone metastasis
  • Tall cell papillary thyroid carcinomas

ASJC Scopus subject areas

  • Medicine(all)

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