Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis

George D. Kymionis, David Goldman, Takeshi Ide, Sonia H Yoo

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

PURPOSE: To report a case of refractory giant papillary conjunctivitis (GPC) treated by using topical tacrolimus 0.03% ointment. METHODS: A 16-year-old white boy with a history of GPC was referred to our department for severe GPC with eye itching, tearing, photophobia, discharge, and blepharospasm. The patient had received previous treatments with antihistamines, mast cell stabilizers, topical corticosteroid ointments, and surgical resection-cryopexy of GPC that were ineffective. RESULTS: Topical tacrolimus 0.03% ointment (Protopic; 0.5 cm) was applied into the lower fornix twice a day. An improvement of the patient's symptoms was observed during the first 5 days of therapy, and the GPC was resolved within 15 days. After 1 month of continued topical tacrolimus ointment treatment, there was no evidence of GPC. Topical tacrolimus was tapered during the next 2 months. Six months after treatment, there were no GPC findings, and no side effects were reported. CONCLUSIONS: Topical tacrolimus 0.03% ointment for severe GPC, refractory to conventional therapy, appears to be an effective alternative treatment.

Original languageEnglish
Pages (from-to)228-229
Number of pages2
JournalCornea
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2008

Fingerprint

Allergic Conjunctivitis
Tacrolimus
Ointments
Therapeutics
Blepharospasm
Photophobia
Histamine Antagonists
Pruritus
Mast Cells
Adrenal Cortex Hormones

Keywords

  • Giant papillary conjunctivitis
  • Refractory
  • Tacrolimus 0.03%

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. / Kymionis, George D.; Goldman, David; Ide, Takeshi; Yoo, Sonia H.

In: Cornea, Vol. 27, No. 2, 01.02.2008, p. 228-229.

Research output: Contribution to journalArticle

Kymionis, George D. ; Goldman, David ; Ide, Takeshi ; Yoo, Sonia H. / Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. In: Cornea. 2008 ; Vol. 27, No. 2. pp. 228-229.
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