T lymphocyte subpopulations in high-risk infants

Influence of age and blood transfusions

Savita G Pahwa, C. Sia, R. Harper, Rajendra Pahwa

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Methodology was established to analyze T lymphocytes and T cell subsets with monoclonal antibodies on microsamples of blood obtained by heel puncture in infants. Results in 39 high-risk infants indicated that during the early neonatal period they had a higher percentage of T4-bearing cells and a lower percentage of T8 antigen-positive cells as compared with adults. These values progressively approached adult values, and at 3 to 7 months the T cell subsets and the T4/t8 ratios were within the adult range. A significant inverse relationship was noted between the number of blood transfusions given to the infants between 2 and 12 weeks of age and the corresponding T4/T8 ratio. These findings suggest that interpretation of T cell subsets in frequently transfused infants should take into consideration not only the age of the infant but also the possible influence of transfusions per se on the distribution of T cell subsets in the peripheral blood.

Original languageEnglish
Pages (from-to)914-917
Number of pages4
JournalPediatrics
Volume76
Issue number6
StatePublished - Dec 1 1985
Externally publishedYes

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Lymphocyte Subsets
Blood Transfusion
T-Lymphocyte Subsets
T-Lymphocytes
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes
Heel
Punctures
Monoclonal Antibodies
Antigens

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

T lymphocyte subpopulations in high-risk infants : Influence of age and blood transfusions. / Pahwa, Savita G; Sia, C.; Harper, R.; Pahwa, Rajendra.

In: Pediatrics, Vol. 76, No. 6, 01.12.1985, p. 914-917.

Research output: Contribution to journalArticle

Pahwa, Savita G ; Sia, C. ; Harper, R. ; Pahwa, Rajendra. / T lymphocyte subpopulations in high-risk infants : Influence of age and blood transfusions. In: Pediatrics. 1985 ; Vol. 76, No. 6. pp. 914-917.
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