T-lymphocyte subpopulations in acute unilateral optic neuritis

John Guy, N. T. Feldberg, P. J. Savino, N. J. Schatz, R. C. Sergott

Research output: Contribution to journalArticle

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Abstract

The authors prospectively analyzed T-lymphocyte subpopulations in the peripheral blood of nine patients with acute unilateral optic neuritis and compared them with 25 controls without neurologic disease. The presence of absence of alterations in circulating T-cell subsets has not been examined previously in patients with isolated optic neuritis. The authors found the mean ratio of inducer (CD4) to suppressor (CD8) T-lymphocytes was 2.07 ± 0.51 for the group with optic neuritis, statistically indistinguishable from a value of 1.78 ± 1.04 for the control group. Multiple sclerosis (MS) subsequently developed in one patient. Her inducer/suppressor T-cell ratio was initially 2.66, but progressively increased to 3.68 concomitant with the clinical manifestation of focal neurologic signs. Although optic neuritis may be the initial clinical sign of MS, the periodic alteration of circulating T-lymphocytes increasing the inducer/suppressor T-cell ratio in MS was not observed in those with isolated optic neuritis.

Original languageEnglish
Pages (from-to)1054-1057
Number of pages4
JournalOphthalmology
Volume96
Issue number7
StatePublished - Jan 1 1989
Externally publishedYes

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Optic Neuritis
Lymphocyte Subsets
T-Lymphocytes
Multiple Sclerosis
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
Neurologic Manifestations
Nervous System Diseases
Control Groups

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Guy, J., Feldberg, N. T., Savino, P. J., Schatz, N. J., & Sergott, R. C. (1989). T-lymphocyte subpopulations in acute unilateral optic neuritis. Ophthalmology, 96(7), 1054-1057.

T-lymphocyte subpopulations in acute unilateral optic neuritis. / Guy, John; Feldberg, N. T.; Savino, P. J.; Schatz, N. J.; Sergott, R. C.

In: Ophthalmology, Vol. 96, No. 7, 01.01.1989, p. 1054-1057.

Research output: Contribution to journalArticle

Guy, J, Feldberg, NT, Savino, PJ, Schatz, NJ & Sergott, RC 1989, 'T-lymphocyte subpopulations in acute unilateral optic neuritis', Ophthalmology, vol. 96, no. 7, pp. 1054-1057.
Guy J, Feldberg NT, Savino PJ, Schatz NJ, Sergott RC. T-lymphocyte subpopulations in acute unilateral optic neuritis. Ophthalmology. 1989 Jan 1;96(7):1054-1057.
Guy, John ; Feldberg, N. T. ; Savino, P. J. ; Schatz, N. J. ; Sergott, R. C. / T-lymphocyte subpopulations in acute unilateral optic neuritis. In: Ophthalmology. 1989 ; Vol. 96, No. 7. pp. 1054-1057.
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