T helper cells, IL-2 and the generation of cytotoxic T-cell responses

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

CD8 T-cell immunity is thought to require helper activity derived from CD4 T cells. Nevertheless, under some circumstances, effective CD8-dependent T-cell responses occur in vivo without CD4 T-cell help. Several recent papers help to explain this paradox and lead to a refined view concerning the role of T helper cells and interleukin-2 receptor signaling in the production of cytotoxic T lymphocytes.

Original languageEnglish
Pages (from-to)465-467
Number of pages3
JournalTrends in Immunology
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2002

Fingerprint

Helper-Inducer T-Lymphocytes
Interleukin-2
T-Lymphocytes
Interleukin-2 Receptors
Cytotoxic T-Lymphocytes
Immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

T helper cells, IL-2 and the generation of cytotoxic T-cell responses. / Malek, Thomas.

In: Trends in Immunology, Vol. 23, No. 10, 01.10.2002, p. 465-467.

Research output: Contribution to journalArticle

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