T helper cells, IL-2 and the generation of cytotoxic T-cell responses

Research output: Contribution to journalReview article

36 Scopus citations


CD8 T-cell immunity is thought to require helper activity derived from CD4 T cells. Nevertheless, under some circumstances, effective CD8-dependent T-cell responses occur in vivo without CD4 T-cell help. Several recent papers help to explain this paradox and lead to a refined view concerning the role of T helper cells and interleukin-2 receptor signaling in the production of cytotoxic T lymphocytes.

Original languageEnglish (US)
Pages (from-to)465-467
Number of pages3
JournalTrends in Immunology
Issue number10
StatePublished - Oct 1 2002


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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