Abstract
T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tfh cells therefore must be tightly controlled to prevent immune dysfunction in the form of autoimmunity and, on the other hand, immune deficiency. Both Tfh and B cell perturbations appear during HIV infection resulting in impaired antibody responses to vaccines such as seasonal trivalent influenza vaccine, also seen in biologic aging. Although many of the HIV-associated defects improve with antiretroviral therapy (ART), excess immune activation and antigen-specific B and T cell responses including Tfh function are still impaired in virologically controlled HIV-infected persons on ART. Interestingly, HIV infected individuals experience increased risk of age-associated pathologies. This review will discuss Tfh and B cell dysfunction in HIV infection and highlight the impact of chronic HIV infection and aging on Tfh-B cell interactions.
| Original language | English (US) |
|---|---|
| Article number | 1380 |
| Journal | Frontiers in Immunology |
| Volume | 8 |
| Issue number | OCT |
| DOIs | |
| State | Published - Oct 23 2017 |
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Keywords
- HIV and aging
- T follicular helper cells and HIV
- T follicular helper cells and immunity
- T follicular helper cells and influenza vaccine
- T follicular helper cells in aging and HIV
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
T follicular helper cells and B cell dysfunction in aging and HIV-1 infection. / Pallikkuth, Suresh; de Armas, Lesley; Rinaldi, Stefano; Pahwa, Savita G.
In: Frontiers in Immunology, Vol. 8, No. OCT, 1380, 23.10.2017.Research output: Contribution to journal › Short survey
}
TY - JOUR
T1 - T follicular helper cells and B cell dysfunction in aging and HIV-1 infection
AU - Pallikkuth, Suresh
AU - de Armas, Lesley
AU - Rinaldi, Stefano
AU - Pahwa, Savita G
PY - 2017/10/23
Y1 - 2017/10/23
N2 - T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tfh cells therefore must be tightly controlled to prevent immune dysfunction in the form of autoimmunity and, on the other hand, immune deficiency. Both Tfh and B cell perturbations appear during HIV infection resulting in impaired antibody responses to vaccines such as seasonal trivalent influenza vaccine, also seen in biologic aging. Although many of the HIV-associated defects improve with antiretroviral therapy (ART), excess immune activation and antigen-specific B and T cell responses including Tfh function are still impaired in virologically controlled HIV-infected persons on ART. Interestingly, HIV infected individuals experience increased risk of age-associated pathologies. This review will discuss Tfh and B cell dysfunction in HIV infection and highlight the impact of chronic HIV infection and aging on Tfh-B cell interactions.
AB - T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tfh cells therefore must be tightly controlled to prevent immune dysfunction in the form of autoimmunity and, on the other hand, immune deficiency. Both Tfh and B cell perturbations appear during HIV infection resulting in impaired antibody responses to vaccines such as seasonal trivalent influenza vaccine, also seen in biologic aging. Although many of the HIV-associated defects improve with antiretroviral therapy (ART), excess immune activation and antigen-specific B and T cell responses including Tfh function are still impaired in virologically controlled HIV-infected persons on ART. Interestingly, HIV infected individuals experience increased risk of age-associated pathologies. This review will discuss Tfh and B cell dysfunction in HIV infection and highlight the impact of chronic HIV infection and aging on Tfh-B cell interactions.
KW - HIV and aging
KW - T follicular helper cells and HIV
KW - T follicular helper cells and immunity
KW - T follicular helper cells and influenza vaccine
KW - T follicular helper cells in aging and HIV
UR - http://www.scopus.com/inward/record.url?scp=85032184217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032184217&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2017.01380
DO - 10.3389/fimmu.2017.01380
M3 - Short survey
AN - SCOPUS:85032184217
VL - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - OCT
M1 - 1380
ER -