TY - JOUR
T1 - T follicular helper cells and B cell dysfunction in aging and HIV-1 infection
AU - Pallikkuth, Suresh
AU - de Armas, Lesley
AU - Rinaldi, Stefano
AU - Pahwa, Savita
N1 - Funding Information:
We thank Dr. Rajendra Pahwa for providing suggestions and critical inputs for the manuscript. This work was supported by funding from National Institutes of Health Grant: R01AI108472 and the Miami Center for AIDS Research (P30AI073961) to SP.
Publisher Copyright:
© 2017 Pallikkuth, de Armas, Rinaldi and Pahwa.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/10/23
Y1 - 2017/10/23
N2 - T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tfh cells therefore must be tightly controlled to prevent immune dysfunction in the form of autoimmunity and, on the other hand, immune deficiency. Both Tfh and B cell perturbations appear during HIV infection resulting in impaired antibody responses to vaccines such as seasonal trivalent influenza vaccine, also seen in biologic aging. Although many of the HIV-associated defects improve with antiretroviral therapy (ART), excess immune activation and antigen-specific B and T cell responses including Tfh function are still impaired in virologically controlled HIV-infected persons on ART. Interestingly, HIV infected individuals experience increased risk of age-associated pathologies. This review will discuss Tfh and B cell dysfunction in HIV infection and highlight the impact of chronic HIV infection and aging on Tfh-B cell interactions.
AB - T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tfh cells therefore must be tightly controlled to prevent immune dysfunction in the form of autoimmunity and, on the other hand, immune deficiency. Both Tfh and B cell perturbations appear during HIV infection resulting in impaired antibody responses to vaccines such as seasonal trivalent influenza vaccine, also seen in biologic aging. Although many of the HIV-associated defects improve with antiretroviral therapy (ART), excess immune activation and antigen-specific B and T cell responses including Tfh function are still impaired in virologically controlled HIV-infected persons on ART. Interestingly, HIV infected individuals experience increased risk of age-associated pathologies. This review will discuss Tfh and B cell dysfunction in HIV infection and highlight the impact of chronic HIV infection and aging on Tfh-B cell interactions.
KW - HIV and aging
KW - T follicular helper cells and HIV
KW - T follicular helper cells and immunity
KW - T follicular helper cells and influenza vaccine
KW - T follicular helper cells in aging and HIV
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U2 - 10.3389/fimmu.2017.01380
DO - 10.3389/fimmu.2017.01380
M3 - Short survey
AN - SCOPUS:85032184217
VL - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - OCT
M1 - 1380
ER -