T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines

Lawrence R. Smith, Dwight H. Kono, Deshratn Asthana, Robert S. Balderas, Yoshitaka Fujii, Jon Lindstrom, Argyrios N. Theofilopoulos

Research output: Contribution to journalArticle

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Abstract

Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.

Original languageEnglish
Pages (from-to)2596-2600
Number of pages5
JournalJournal of Immunology
Volume152
Issue number5
StatePublished - Mar 1 1994
Externally publishedYes

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Cholinergic Receptors
T-Cell Antigen Receptor
T-Lymphocytes
Cell Line
Torpedo

ASJC Scopus subject areas

  • Immunology

Cite this

Smith, L. R., Kono, D. H., Asthana, D., Balderas, R. S., Fujii, Y., Lindstrom, J., & Theofilopoulos, A. N. (1994). T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. Journal of Immunology, 152(5), 2596-2600.

T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. / Smith, Lawrence R.; Kono, Dwight H.; Asthana, Deshratn; Balderas, Robert S.; Fujii, Yoshitaka; Lindstrom, Jon; Theofilopoulos, Argyrios N.

In: Journal of Immunology, Vol. 152, No. 5, 01.03.1994, p. 2596-2600.

Research output: Contribution to journalArticle

Smith, LR, Kono, DH, Asthana, D, Balderas, RS, Fujii, Y, Lindstrom, J & Theofilopoulos, AN 1994, 'T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines', Journal of Immunology, vol. 152, no. 5, pp. 2596-2600.
Smith LR, Kono DH, Asthana D, Balderas RS, Fujii Y, Lindstrom J et al. T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. Journal of Immunology. 1994 Mar 1;152(5):2596-2600.
Smith, Lawrence R. ; Kono, Dwight H. ; Asthana, Deshratn ; Balderas, Robert S. ; Fujii, Yoshitaka ; Lindstrom, Jon ; Theofilopoulos, Argyrios N. / T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. In: Journal of Immunology. 1994 ; Vol. 152, No. 5. pp. 2596-2600.
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