T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines

Lawrence R. Smith, Dwight H. Kono, Deshratn Asthana, Robert S. Balderas, Yoshitaka Fujii, Jon Lindstrom, Argyrios N. Theofilopoulos

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.

Original languageEnglish (US)
Pages (from-to)2596-2600
Number of pages5
JournalJournal of Immunology
Volume152
Issue number5
StatePublished - Mar 1 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Smith, L. R., Kono, D. H., Asthana, D., Balderas, R. S., Fujii, Y., Lindstrom, J., & Theofilopoulos, A. N. (1994). T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. Journal of Immunology, 152(5), 2596-2600.