T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines

Lawrence R. Smith; Dwight H. Kono; Deshratn Asthana; Robert S. Balderas; Yoshitaka Fujii; Jon Lindstrom; Argyrios N. Theofilopoulos

T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines

Lawrence R. Smith, Dwight H. Kono, Deshratn Asthana, Robert S. Balderas, Yoshitaka Fujii, Jon Lindstrom, Argyrios N. Theofilopoulos

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4⁺, OX- 22^-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15⁺ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.

Original language	English (US)
Pages (from-to)	2596-2600
Number of pages	5
Journal	Journal of Immunology
Volume	152
Issue number	5
State	Published - Mar 1 1994

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. / Smith, Lawrence R.; Kono, Dwight H.; Asthana, Deshratn; Balderas, Robert S.; Fujii, Yoshitaka; Lindstrom, Jon; Theofilopoulos, Argyrios N.

In: Journal of Immunology, Vol. 152, No. 5, 01.03.1994, p. 2596-2600.

Research output: Contribution to journal › Article › peer-review

@article{887a5e5352b14f37addbc01bfddd68b0,

title = "T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines",

abstract = "Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.",

author = "Smith, {Lawrence R.} and Kono, {Dwight H.} and Deshratn Asthana and Balderas, {Robert S.} and Yoshitaka Fujii and Jon Lindstrom and Theofilopoulos, {Argyrios N.}",

year = "1994",

month = mar,

day = "1",

language = "English (US)",

volume = "152",

pages = "2596--2600",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "5",

}

TY - JOUR

T1 - T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines

AU - Smith, Lawrence R.

AU - Kono, Dwight H.

AU - Asthana, Deshratn

AU - Balderas, Robert S.

AU - Fujii, Yoshitaka

AU - Lindstrom, Jon

AU - Theofilopoulos, Argyrios N.

PY - 1994/3/1

Y1 - 1994/3/1

N2 - Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.

AB - Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.

UR - http://www.scopus.com/inward/record.url?scp=0028282092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028282092&partnerID=8YFLogxK

M3 - Article

C2 - 8133067

AN - SCOPUS:0028282092

VL - 152

SP - 2596

EP - 2600

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 5

ER -

T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this