Abstract
Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.
| Original language | English |
|---|---|
| Pages (from-to) | 2596-2600 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 152 |
| Issue number | 5 |
| State | Published - Mar 1 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. / Smith, Lawrence R.; Kono, Dwight H.; Asthana, Deshratn; Balderas, Robert S.; Fujii, Yoshitaka; Lindstrom, Jon; Theofilopoulos, Argyrios N.
In: Journal of Immunology, Vol. 152, No. 5, 01.03.1994, p. 2596-2600.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines
AU - Smith, Lawrence R.
AU - Kono, Dwight H.
AU - Asthana, Deshratn
AU - Balderas, Robert S.
AU - Fujii, Yoshitaka
AU - Lindstrom, Jon
AU - Theofilopoulos, Argyrios N.
PY - 1994/3/1
Y1 - 1994/3/1
N2 - Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.
AB - Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.
UR - http://www.scopus.com/inward/record.url?scp=0028282092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028282092&partnerID=8YFLogxK
M3 - Article
VL - 152
SP - 2596
EP - 2600
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 5
ER -