T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines

Lawrence R. Smith; Dwight H. Kono; Deshratn Asthana; Robert S. Balderas; Yoshitaka Fujii; Jon Lindstrom; Argyrios N. Theofilopoulos

T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines

Lawrence R. Smith, Dwight H. Kono, Deshratn Asthana, Robert S. Balderas, Yoshitaka Fujii, Jon Lindstrom, Argyrios N. Theofilopoulos

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4⁺, OX- 22^-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15⁺ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.

Original language	English (US)
Pages (from-to)	2596-2600
Number of pages	5
Journal	Journal of Immunology
Volume	152
Issue number	5
State	Published - Mar 1 1994

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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T cell receptor Vβ15 dominates the antiacetylcholine receptor response in Lewis rat T cell lines. / Smith, Lawrence R.; Kono, Dwight H.; Asthana, Deshratn; Balderas, Robert S.; Fujii, Yoshitaka; Lindstrom, Jon; Theofilopoulos, Argyrios N.

In: Journal of Immunology, Vol. 152, No. 5, 01.03.1994, p. 2596-2600.

Research output: Contribution to journal › Article › peer-review

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abstract = "Ten Lewis rat T cell lines responsive to Torpedo californica acetylcholine receptor (AChR) were assayed for TCR Vβ usage. All lines were CD4+, OX- 22-, and exhibited reactivity to one or more AChR chains. Several different Vβs were expressed by these lines, but Vβ15 was dominant in 5 of 10 lines. Unique CDR3 sequences were observed among the 10 lines, although three of the Vβ15 rearrangements used Jβ1.4. These data suggest that Vβ15+ T cells are selected in the in vitro response to the antigenically complex AChR in the Lewis rat.",

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AU - Lindstrom, Jon

AU - Theofilopoulos, Argyrios N.

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