T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma

Gabriela Gualco, Lawrence M. Weiss, Glen N Barber, Carlos E. Bacchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The physiologic expression of the product of the proto-oncogene TCL1 (T-cell leukemia 1) is primarily restricted to early embryonic cells. In nonneoplastic B cells, the expression of TCL1 is determined by the differentiation step with silencing at the germinal center stage. TCL1 protein is overexpressed in a wide variety of human diseases. It has been shown that TCL1 is a powerful B-cell oncogene, which has been implicated in the pathogenesis of various types of mature B-cell lymphomas. There is no comparative information in the literature addressing the expression of TCL1 in pediatric and adult nodal diffuse large B-cell lymphoma or primary mediastinal large B-cell lymphoma. We studied 55 cases of adult and pediatric diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma to analyze the phenotypic profile of these lymphomas, including TCL1 expression, and its relationship with clinical outcome in different age groups. The cases were analyzed by immunohistochemistry for the expression of TCL1, CD10, BCL-2, BCL-6, and MUM1. We also evaluated c-MYC translocation by fluorescence in situ hybridization. TCL1 was observed in 11 cases, 5 pediatric and 6 adult cases, all but one diffuse large B-cell lymphoma. Pediatric cases showed a significant association between TCL1 expression, high proliferative index, and presence of c-MYC translocation. TCL1 positivity was predominantly found in germinal center phenotype diffuse large B-cell lymphoma. Overall survival was worse in adult TCL1-positive cases than pediatric ones. Primary mediastinal large B-cell lymphomas infrequently expressed TCL1 in both age groups.

Original languageEnglish
Pages (from-to)1238-1244
Number of pages7
JournalHuman Pathology
Volume41
Issue number9
DOIs
StatePublished - Sep 1 2010

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T-Cell Leukemia
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Human Herpesvirus 4
Pediatrics
Germinal Center
B-Lymphocytes
Age Groups
Adult T Cell Leukemia Lymphoma
Proto-Oncogenes
Fluorescence In Situ Hybridization
Oncogenes
Lymphoma
Immunohistochemistry

Keywords

  • C-MYC
  • DLBCL
  • EBV
  • FISH
  • Immunohistochemistry
  • Malignant lymphoma
  • MUM1/IRF4
  • PMBCL
  • TCL-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. / Gualco, Gabriela; Weiss, Lawrence M.; Barber, Glen N; Bacchi, Carlos E.

In: Human Pathology, Vol. 41, No. 9, 01.09.2010, p. 1238-1244.

Research output: Contribution to journalArticle

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