The FANFT-induced bladder cancer murine model was used to evaluate the effect of DDP and MMC on the incidence and size of subsequent tumors. MMC was at least equally effective as DDP in inhibiting tumor growth in this model. There was no apparent synergistic effect when the two agents were combined although toxicity was increased. Further clinical trials with systemic MMC for locally advanced or metastatic urothelial transitional cell carcinoma appear to be indicated.
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