Abstract
Objectives: This study aimed to compare the difference of the clinical and laboratory features of the patients between the combined systemic lupus erythematosus (SLE) and Sjögren syndrome (SLE-SS) and SLE only. Materials and Methods: A systematic literature search was performed to identify the articles as to SLE with SS between 1970 and May 2011. The demographics, pertinent clinical, and laboratory data were extracted from 6 publications, and a meta-analysis was performed. The pooled odds ratios and 95% confidence interval were computed for the variability of these parameters between SLE-SS and SLE. Results: A total of 6 studies were included, consisting of 2489 patients with SLE and 444 with SLE-SS, and the estimated prevalence of the latter was 17.8%. Patients with SLE-SS were older and more often had associated oral ulcers and arthritis. In contrast, proteinuria (odds ratio = 1.77; 95% confidence interval, 1.39-2.25; P <0.0001) was more common in SLE alone than SLE-SS, and central nervous system involvement tended to be more common. Anti-double-stranded DNA antibodies were equally prevalent in both groups. Anti-SSA/Ro and anti-SSB/La antibodies were more frequent, and anti-Sm and anti-cardiolipin antibodies were less prevalent in SLE-SS than SLE alone. Conclusions: There are significant variances in certain clinical and laboratory aspects between SLE-SS and SLE. This combined disease of SLE-SS has distinct features with relatively less major internal organ involvement but has more specific autoantibody profile and favorable clinical outcome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28-32 |
| Number of pages | 5 |
| Journal | Journal of Clinical Rheumatology |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2012 |
| Externally published | Yes |
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Keywords
- antiYdouble-stranded DNA antibodies
- meta-analysis
- Sjögren syndrome
- systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
Cite this
Systemic lupus erythematosus with sjögren syndrome compared to systemic lupus erythematosus alone : A meta-analysis. / Yao, Qingping; Altman, Roy D; Wang, Xiaofeng.
In: Journal of Clinical Rheumatology, Vol. 18, No. 1, 01.2012, p. 28-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Systemic lupus erythematosus with sjögren syndrome compared to systemic lupus erythematosus alone
T2 - A meta-analysis
AU - Yao, Qingping
AU - Altman, Roy D
AU - Wang, Xiaofeng
PY - 2012/1
Y1 - 2012/1
N2 - Objectives: This study aimed to compare the difference of the clinical and laboratory features of the patients between the combined systemic lupus erythematosus (SLE) and Sjögren syndrome (SLE-SS) and SLE only. Materials and Methods: A systematic literature search was performed to identify the articles as to SLE with SS between 1970 and May 2011. The demographics, pertinent clinical, and laboratory data were extracted from 6 publications, and a meta-analysis was performed. The pooled odds ratios and 95% confidence interval were computed for the variability of these parameters between SLE-SS and SLE. Results: A total of 6 studies were included, consisting of 2489 patients with SLE and 444 with SLE-SS, and the estimated prevalence of the latter was 17.8%. Patients with SLE-SS were older and more often had associated oral ulcers and arthritis. In contrast, proteinuria (odds ratio = 1.77; 95% confidence interval, 1.39-2.25; P <0.0001) was more common in SLE alone than SLE-SS, and central nervous system involvement tended to be more common. Anti-double-stranded DNA antibodies were equally prevalent in both groups. Anti-SSA/Ro and anti-SSB/La antibodies were more frequent, and anti-Sm and anti-cardiolipin antibodies were less prevalent in SLE-SS than SLE alone. Conclusions: There are significant variances in certain clinical and laboratory aspects between SLE-SS and SLE. This combined disease of SLE-SS has distinct features with relatively less major internal organ involvement but has more specific autoantibody profile and favorable clinical outcome.
AB - Objectives: This study aimed to compare the difference of the clinical and laboratory features of the patients between the combined systemic lupus erythematosus (SLE) and Sjögren syndrome (SLE-SS) and SLE only. Materials and Methods: A systematic literature search was performed to identify the articles as to SLE with SS between 1970 and May 2011. The demographics, pertinent clinical, and laboratory data were extracted from 6 publications, and a meta-analysis was performed. The pooled odds ratios and 95% confidence interval were computed for the variability of these parameters between SLE-SS and SLE. Results: A total of 6 studies were included, consisting of 2489 patients with SLE and 444 with SLE-SS, and the estimated prevalence of the latter was 17.8%. Patients with SLE-SS were older and more often had associated oral ulcers and arthritis. In contrast, proteinuria (odds ratio = 1.77; 95% confidence interval, 1.39-2.25; P <0.0001) was more common in SLE alone than SLE-SS, and central nervous system involvement tended to be more common. Anti-double-stranded DNA antibodies were equally prevalent in both groups. Anti-SSA/Ro and anti-SSB/La antibodies were more frequent, and anti-Sm and anti-cardiolipin antibodies were less prevalent in SLE-SS than SLE alone. Conclusions: There are significant variances in certain clinical and laboratory aspects between SLE-SS and SLE. This combined disease of SLE-SS has distinct features with relatively less major internal organ involvement but has more specific autoantibody profile and favorable clinical outcome.
KW - antiYdouble-stranded DNA antibodies
KW - meta-analysis
KW - Sjögren syndrome
KW - systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84855207957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855207957&partnerID=8YFLogxK
U2 - 10.1097/RHU.0b013e31823ecbdf
DO - 10.1097/RHU.0b013e31823ecbdf
M3 - Article
C2 - 22157271
AN - SCOPUS:84855207957
VL - 18
SP - 28
EP - 32
JO - Journal of Clinical Rheumatology
JF - Journal of Clinical Rheumatology
SN - 1076-1608
IS - 1
ER -