Systemic lupus erythematosus with sjögren syndrome compared to systemic lupus erythematosus alone: A meta-analysis

Qingping Yao, Roy D Altman, Xiaofeng Wang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives: This study aimed to compare the difference of the clinical and laboratory features of the patients between the combined systemic lupus erythematosus (SLE) and Sjögren syndrome (SLE-SS) and SLE only. Materials and Methods: A systematic literature search was performed to identify the articles as to SLE with SS between 1970 and May 2011. The demographics, pertinent clinical, and laboratory data were extracted from 6 publications, and a meta-analysis was performed. The pooled odds ratios and 95% confidence interval were computed for the variability of these parameters between SLE-SS and SLE. Results: A total of 6 studies were included, consisting of 2489 patients with SLE and 444 with SLE-SS, and the estimated prevalence of the latter was 17.8%. Patients with SLE-SS were older and more often had associated oral ulcers and arthritis. In contrast, proteinuria (odds ratio = 1.77; 95% confidence interval, 1.39-2.25; P <0.0001) was more common in SLE alone than SLE-SS, and central nervous system involvement tended to be more common. Anti-double-stranded DNA antibodies were equally prevalent in both groups. Anti-SSA/Ro and anti-SSB/La antibodies were more frequent, and anti-Sm and anti-cardiolipin antibodies were less prevalent in SLE-SS than SLE alone. Conclusions: There are significant variances in certain clinical and laboratory aspects between SLE-SS and SLE. This combined disease of SLE-SS has distinct features with relatively less major internal organ involvement but has more specific autoantibody profile and favorable clinical outcome.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalJournal of Clinical Rheumatology
Volume18
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Systemic Lupus Erythematosus
Meta-Analysis
Odds Ratio
Confidence Intervals
Oral Ulcer
Cardiolipins
Antibodies
Proteinuria
Autoantibodies
Arthritis
Publications
Anti-Idiotypic Antibodies
Central Nervous System
Demography

Keywords

  • antiYdouble-stranded DNA antibodies
  • meta-analysis
  • Sjögren syndrome
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Systemic lupus erythematosus with sjögren syndrome compared to systemic lupus erythematosus alone : A meta-analysis. / Yao, Qingping; Altman, Roy D; Wang, Xiaofeng.

In: Journal of Clinical Rheumatology, Vol. 18, No. 1, 01.2012, p. 28-32.

Research output: Contribution to journalArticle

@article{861472941ca6441eb6a15610522b37f6,
title = "Systemic lupus erythematosus with sj{\"o}gren syndrome compared to systemic lupus erythematosus alone: A meta-analysis",
abstract = "Objectives: This study aimed to compare the difference of the clinical and laboratory features of the patients between the combined systemic lupus erythematosus (SLE) and Sj{\"o}gren syndrome (SLE-SS) and SLE only. Materials and Methods: A systematic literature search was performed to identify the articles as to SLE with SS between 1970 and May 2011. The demographics, pertinent clinical, and laboratory data were extracted from 6 publications, and a meta-analysis was performed. The pooled odds ratios and 95{\%} confidence interval were computed for the variability of these parameters between SLE-SS and SLE. Results: A total of 6 studies were included, consisting of 2489 patients with SLE and 444 with SLE-SS, and the estimated prevalence of the latter was 17.8{\%}. Patients with SLE-SS were older and more often had associated oral ulcers and arthritis. In contrast, proteinuria (odds ratio = 1.77; 95{\%} confidence interval, 1.39-2.25; P <0.0001) was more common in SLE alone than SLE-SS, and central nervous system involvement tended to be more common. Anti-double-stranded DNA antibodies were equally prevalent in both groups. Anti-SSA/Ro and anti-SSB/La antibodies were more frequent, and anti-Sm and anti-cardiolipin antibodies were less prevalent in SLE-SS than SLE alone. Conclusions: There are significant variances in certain clinical and laboratory aspects between SLE-SS and SLE. This combined disease of SLE-SS has distinct features with relatively less major internal organ involvement but has more specific autoantibody profile and favorable clinical outcome.",
keywords = "antiYdouble-stranded DNA antibodies, meta-analysis, Sj{\"o}gren syndrome, systemic lupus erythematosus",
author = "Qingping Yao and Altman, {Roy D} and Xiaofeng Wang",
year = "2012",
month = "1",
doi = "10.1097/RHU.0b013e31823ecbdf",
language = "English (US)",
volume = "18",
pages = "28--32",
journal = "Journal of Clinical Rheumatology",
issn = "1076-1608",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Systemic lupus erythematosus with sjögren syndrome compared to systemic lupus erythematosus alone

T2 - A meta-analysis

AU - Yao, Qingping

AU - Altman, Roy D

AU - Wang, Xiaofeng

PY - 2012/1

Y1 - 2012/1

N2 - Objectives: This study aimed to compare the difference of the clinical and laboratory features of the patients between the combined systemic lupus erythematosus (SLE) and Sjögren syndrome (SLE-SS) and SLE only. Materials and Methods: A systematic literature search was performed to identify the articles as to SLE with SS between 1970 and May 2011. The demographics, pertinent clinical, and laboratory data were extracted from 6 publications, and a meta-analysis was performed. The pooled odds ratios and 95% confidence interval were computed for the variability of these parameters between SLE-SS and SLE. Results: A total of 6 studies were included, consisting of 2489 patients with SLE and 444 with SLE-SS, and the estimated prevalence of the latter was 17.8%. Patients with SLE-SS were older and more often had associated oral ulcers and arthritis. In contrast, proteinuria (odds ratio = 1.77; 95% confidence interval, 1.39-2.25; P <0.0001) was more common in SLE alone than SLE-SS, and central nervous system involvement tended to be more common. Anti-double-stranded DNA antibodies were equally prevalent in both groups. Anti-SSA/Ro and anti-SSB/La antibodies were more frequent, and anti-Sm and anti-cardiolipin antibodies were less prevalent in SLE-SS than SLE alone. Conclusions: There are significant variances in certain clinical and laboratory aspects between SLE-SS and SLE. This combined disease of SLE-SS has distinct features with relatively less major internal organ involvement but has more specific autoantibody profile and favorable clinical outcome.

AB - Objectives: This study aimed to compare the difference of the clinical and laboratory features of the patients between the combined systemic lupus erythematosus (SLE) and Sjögren syndrome (SLE-SS) and SLE only. Materials and Methods: A systematic literature search was performed to identify the articles as to SLE with SS between 1970 and May 2011. The demographics, pertinent clinical, and laboratory data were extracted from 6 publications, and a meta-analysis was performed. The pooled odds ratios and 95% confidence interval were computed for the variability of these parameters between SLE-SS and SLE. Results: A total of 6 studies were included, consisting of 2489 patients with SLE and 444 with SLE-SS, and the estimated prevalence of the latter was 17.8%. Patients with SLE-SS were older and more often had associated oral ulcers and arthritis. In contrast, proteinuria (odds ratio = 1.77; 95% confidence interval, 1.39-2.25; P <0.0001) was more common in SLE alone than SLE-SS, and central nervous system involvement tended to be more common. Anti-double-stranded DNA antibodies were equally prevalent in both groups. Anti-SSA/Ro and anti-SSB/La antibodies were more frequent, and anti-Sm and anti-cardiolipin antibodies were less prevalent in SLE-SS than SLE alone. Conclusions: There are significant variances in certain clinical and laboratory aspects between SLE-SS and SLE. This combined disease of SLE-SS has distinct features with relatively less major internal organ involvement but has more specific autoantibody profile and favorable clinical outcome.

KW - antiYdouble-stranded DNA antibodies

KW - meta-analysis

KW - Sjögren syndrome

KW - systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=84855207957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855207957&partnerID=8YFLogxK

U2 - 10.1097/RHU.0b013e31823ecbdf

DO - 10.1097/RHU.0b013e31823ecbdf

M3 - Article

C2 - 22157271

AN - SCOPUS:84855207957

VL - 18

SP - 28

EP - 32

JO - Journal of Clinical Rheumatology

JF - Journal of Clinical Rheumatology

SN - 1076-1608

IS - 1

ER -