Systemic fentanyl enhances the spread of spinal analgesia produced by lignocaine

A. Fassoulaki, C. Sarantopoulos, S. Chondreli

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20 Scopus citations


Seventy-one patients undergoing transurethral prostatectomy under spinal anaesthesia were allocated randomly to one of four groups; fentanyl-naloxone (F-Nal), fentanyl-normal saline (F-NS), normal saline-naloxone (NS-Nal), and normal saline-normal saline (NS-NS) group. Twenty minutes after subarachnoid injection of hyperbaric lignocaine 100 mg, we tested the level of spinal analgesia (pinprick sensation) and administered i.v. either fentanyl 100/μg (F-Nal and F-NS groups) or normal saline 2 ml (NS-Nal and NS-NS groups). Ten minutes later, we assessed the new levels of analgesia and administered i.v. either naloxone 0.4 mg (F-Nal and NS-Nal groups) or normal saline 1 ml (F-NS and NS-NS groups). The level of sensory block was reassessed 10 min after the naloxone or normal saline treatment. Ten minutes after i.v. administration of fentanyl or normal saline, the level of analgesia increased in the F-Nal and F-NS groups by 3.98 and 3.78 cm, respectively, and differed significantly compared with the NS-Nal and NS-NS groups (both P < 0.01). Forty minutes after spinal block, the decrease in analgesia in the F-Nal group (3.97 cm) differed significantly from that in the other groups (P < 0.01). Systemic fentanyl enhanced the spread of analgesia. This enhancement was antagonized by naloxone.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalBritish Journal of Anaesthesia
Issue number4
StatePublished - Oct 1991
Externally publishedYes


  • Anaesthetic techniques Spinal
  • Analgesics
  • Fentanyl
  • Lignocaine
  • Local anaesthetics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)


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