Systemic cyclopentolate (Cyclogyl) toxicity in the newborn infant

Wliiam L. Nyhan; Harry C. Shirkey; Charles R. Bauer; Marie Claire Trepanier Trottier; Leo Stern

doi:10.1016/S0022-3476(73)80134-9

Systemic cyclopentolate (Cyclogyl) toxicity in the newborn infant

Wliiam L. Nyhan, Harry C. Shirkey, Charles R. Bauer, Marie Claire Trepanier Trottier, Leo Stern

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Two cases of atropine-like toxicity following the ocular administration of cyclopentolate hydrochloride (Cyclogyl) in a pair of premature Negro twins are reported. The symptoms were confined to the gastrointestinal tract with vomiting, distension, and ileus. Both infants apparently recovered from the initial episode, but one of the twins subsequently died from necrotizing enterocolitis complicated by an intestinal perforation. In both children systemic concentrations of the drug supported the clinical impression of Cyclogyl intoxication.

Original language	English (US)
Pages (from-to)	501-505
Number of pages	5
Journal	The Journal of Pediatrics
Volume	82
Issue number	3
DOIs	https://doi.org/10.1016/S0022-3476(73)80134-9
State	Published - Mar 1973
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(73)80134-9

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@article{5811facc9d6e437086ef65294faa0a87,

title = "Systemic cyclopentolate (Cyclogyl) toxicity in the newborn infant",

abstract = "Two cases of atropine-like toxicity following the ocular administration of cyclopentolate hydrochloride (Cyclogyl) in a pair of premature Negro twins are reported. The symptoms were confined to the gastrointestinal tract with vomiting, distension, and ileus. Both infants apparently recovered from the initial episode, but one of the twins subsequently died from necrotizing enterocolitis complicated by an intestinal perforation. In both children systemic concentrations of the drug supported the clinical impression of Cyclogyl intoxication.",

author = "Nyhan, {Wliiam L.} and Shirkey, {Harry C.} and Bauer, {Charles R.} and {Trepanier Trottier}, {Marie Claire} and Leo Stern",

note = "Funding Information: From the Department o\[ Newborn Medicine, The Montreal Children's Hospital, and the Department o\[ Pediatrics, McGill University. Supported in part by Grant MA-3037 \[rom the Medical Research Council o\[ Canada.",

year = "1973",

month = mar,

doi = "10.1016/S0022-3476(73)80134-9",

language = "English (US)",

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pages = "501--505",

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T1 - Systemic cyclopentolate (Cyclogyl) toxicity in the newborn infant

AU - Nyhan, Wliiam L.

AU - Shirkey, Harry C.

AU - Bauer, Charles R.

AU - Trepanier Trottier, Marie Claire

AU - Stern, Leo

N1 - Funding Information: From the Department o\[ Newborn Medicine, The Montreal Children's Hospital, and the Department o\[ Pediatrics, McGill University. Supported in part by Grant MA-3037 \[rom the Medical Research Council o\[ Canada.

PY - 1973/3

Y1 - 1973/3

N2 - Two cases of atropine-like toxicity following the ocular administration of cyclopentolate hydrochloride (Cyclogyl) in a pair of premature Negro twins are reported. The symptoms were confined to the gastrointestinal tract with vomiting, distension, and ileus. Both infants apparently recovered from the initial episode, but one of the twins subsequently died from necrotizing enterocolitis complicated by an intestinal perforation. In both children systemic concentrations of the drug supported the clinical impression of Cyclogyl intoxication.

AB - Two cases of atropine-like toxicity following the ocular administration of cyclopentolate hydrochloride (Cyclogyl) in a pair of premature Negro twins are reported. The symptoms were confined to the gastrointestinal tract with vomiting, distension, and ileus. Both infants apparently recovered from the initial episode, but one of the twins subsequently died from necrotizing enterocolitis complicated by an intestinal perforation. In both children systemic concentrations of the drug supported the clinical impression of Cyclogyl intoxication.

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EP - 505

JO - Journal of Pediatrics

JF - Journal of Pediatrics

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ER -

Systemic cyclopentolate (Cyclogyl) toxicity in the newborn infant

Abstract

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