Systemic cyclopentolate (Cyclogyl) toxicity in the newborn infant

Wliiam L. Nyhan; Harry C. Shirkey; Charles R. Bauer; Marie Claire Trepanier Trottier; Leo Stern

doi:10.1016/S0022-3476(73)80134-9

Systemic cyclopentolate (Cyclogyl) toxicity in the newborn infant

Wliiam L. Nyhan, Harry C. Shirkey, Charles R. Bauer, Marie Claire Trepanier Trottier, Leo Stern

Pediatrics

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Two cases of atropine-like toxicity following the ocular administration of cyclopentolate hydrochloride (Cyclogyl) in a pair of premature Negro twins are reported. The symptoms were confined to the gastrointestinal tract with vomiting, distension, and ileus. Both infants apparently recovered from the initial episode, but one of the twins subsequently died from necrotizing enterocolitis complicated by an intestinal perforation. In both children systemic concentrations of the drug supported the clinical impression of Cyclogyl intoxication.

Original language	English (US)
Pages (from-to)	501-505
Number of pages	5
Journal	The Journal of Pediatrics
Volume	82
Issue number	3
DOIs	https://doi.org/10.1016/S0022-3476(73)80134-9
State	Published - Mar 1973

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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abstract = "Two cases of atropine-like toxicity following the ocular administration of cyclopentolate hydrochloride (Cyclogyl) in a pair of premature Negro twins are reported. The symptoms were confined to the gastrointestinal tract with vomiting, distension, and ileus. Both infants apparently recovered from the initial episode, but one of the twins subsequently died from necrotizing enterocolitis complicated by an intestinal perforation. In both children systemic concentrations of the drug supported the clinical impression of Cyclogyl intoxication.",

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AU - Nyhan, Wliiam L.

AU - Shirkey, Harry C.

AU - Bauer, Charles R.

AU - Trepanier Trottier, Marie Claire

AU - Stern, Leo

PY - 1973/3

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AB - Two cases of atropine-like toxicity following the ocular administration of cyclopentolate hydrochloride (Cyclogyl) in a pair of premature Negro twins are reported. The symptoms were confined to the gastrointestinal tract with vomiting, distension, and ileus. Both infants apparently recovered from the initial episode, but one of the twins subsequently died from necrotizing enterocolitis complicated by an intestinal perforation. In both children systemic concentrations of the drug supported the clinical impression of Cyclogyl intoxication.

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