Systemic chimerism in human female recipients of male livers

Thomas E. Starzl, Antony J. Demetris, Massimo Trucco, Camillo Ricordi, Adriana Zeevi, William A. Rudert, Mirjana Kocova, Camillo Ricordi, Suzanne Ildstad, Noriko Murase

Research output: Contribution to journalArticle

299 Citations (Scopus)

Abstract

We have previously reported data from clinical and laboratory animal observations which suggest that organ tolerance after transplantation depends on a state of balanced lymphodendritic cell chimerism between the host and donor graft. We have sought further evidence to support this hypothesis by investigating HLA-mismatched liver allograft recipients. 9 of 9 female recipients of livers from male donors had chimerism in their allografts and extrahepatic tissues, according to in-situ hybridisation and molecular techniques 10 to 19 years post-transplantation. In 8 women with good graft function, evidence of the Y chromosome was found in the blood (6/8), skin (8/8), and lymph nodes (7/8). A ninth patient whose transplant failed after 12 years from recurrent chronic viral hepatitis had chimerism in her lymph nodes, skin, jejunum, and aorta at the time of retransplantation. Although cell migration is thought to take place after all types of transplantation, the large population of migratory cells in, and the extent of their seeding from, hepatic grafts may explain the privileged tolerogenicity of the liver compared with other organs.

Original languageEnglish
Pages (from-to)876-877
Number of pages2
JournalLancet
Volume340
Issue number8824
StatePublished - Dec 1 1992
Externally publishedYes

Fingerprint

Chimerism
Transplants
Liver
Allografts
Transplantation
Lymph Nodes
Tissue Donors
Transplantation Tolerance
Skin
Y Chromosome
Laboratory Animals
Jejunum
Chronic Hepatitis
Cell Movement
In Situ Hybridization
Aorta
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Starzl, T. E., Demetris, A. J., Trucco, M., Ricordi, C., Zeevi, A., Rudert, W. A., ... Murase, N. (1992). Systemic chimerism in human female recipients of male livers. Lancet, 340(8824), 876-877.

Systemic chimerism in human female recipients of male livers. / Starzl, Thomas E.; Demetris, Antony J.; Trucco, Massimo; Ricordi, Camillo; Zeevi, Adriana; Rudert, William A.; Kocova, Mirjana; Ricordi, Camillo; Ildstad, Suzanne; Murase, Noriko.

In: Lancet, Vol. 340, No. 8824, 01.12.1992, p. 876-877.

Research output: Contribution to journalArticle

Starzl, TE, Demetris, AJ, Trucco, M, Ricordi, C, Zeevi, A, Rudert, WA, Kocova, M, Ricordi, C, Ildstad, S & Murase, N 1992, 'Systemic chimerism in human female recipients of male livers', Lancet, vol. 340, no. 8824, pp. 876-877.
Starzl TE, Demetris AJ, Trucco M, Ricordi C, Zeevi A, Rudert WA et al. Systemic chimerism in human female recipients of male livers. Lancet. 1992 Dec 1;340(8824):876-877.
Starzl, Thomas E. ; Demetris, Antony J. ; Trucco, Massimo ; Ricordi, Camillo ; Zeevi, Adriana ; Rudert, William A. ; Kocova, Mirjana ; Ricordi, Camillo ; Ildstad, Suzanne ; Murase, Noriko. / Systemic chimerism in human female recipients of male livers. In: Lancet. 1992 ; Vol. 340, No. 8824. pp. 876-877.
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