System for on-and off-axis volumetric OCT imaging and ray tracing aberrometry of the crystalline lens

Marco Ruggeri; Siobhan Williams; Bianca Maceo Heilman; Yue Yao; Yu Cherng Chang; Ashik Mohamed; N. Geetha Sravani; Heather Durkee; Cornelis Rowaan; Alex Gonzalez; Arthur Ho; Jean Marie Parel; Fabrice Manns

doi:10.1364/BOE.9.003834

System for on-and off-axis volumetric OCT imaging and ray tracing aberrometry of the crystalline lens

Marco Ruggeri, Siobhan Williams, Bianca Maceo Heilman, Yue Yao, Yu Cherng Chang, Ashik Mohamed, N. Geetha Sravani, Heather Durkee, Cornelis Rowaan, Alex Gonzalez, Arthur Ho, Jean Marie Parel, Fabrice Manns

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We present a new in vitro instrument for measuring shape and wavefront aberrations of the primate crystalline lens, both on-and off-axis, while simulating accommodation with a motorized lens stretching system. The instrument merges spectral domain optical coherence tomography (SD-OCT) imaging and ray tracing aberrometry using an approach that senses wavefront aberrations of the lens with the OCT probing beam. Accuracy and repeatability of aberration measurements were quantified. Preliminary experiments on two human and four cynomolgus monkey lenses demonstrate the ability of the system to measure the lens shape, spherical aberration and peripheral defocus, and their changes during simulated accommodation.

Original language	English (US)
Article number	332332
Pages (from-to)	3834-3851
Number of pages	18
Journal	Biomedical Optics Express
Volume	9
Issue number	8
DOIs	https://doi.org/10.1364/BOE.9.003834
State	Published - Aug 1 2018

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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System for on-and off-axis volumetric OCT imaging and ray tracing aberrometry of the crystalline lens. / Ruggeri, Marco; Williams, Siobhan; Heilman, Bianca Maceo; Yao, Yue; Chang, Yu Cherng; Mohamed, Ashik; Sravani, N. Geetha; Durkee, Heather; Rowaan, Cornelis; Gonzalez, Alex; Ho, Arthur; Parel, Jean Marie ; Manns, Fabrice.

In: Biomedical Optics Express, Vol. 9, No. 8, 332332, 01.08.2018, p. 3834-3851.

Research output: Contribution to journal › Article › peer-review

Ruggeri, Marco ; Williams, Siobhan ; Heilman, Bianca Maceo ; Yao, Yue ; Chang, Yu Cherng ; Mohamed, Ashik ; Sravani, N. Geetha ; Durkee, Heather ; Rowaan, Cornelis ; Gonzalez, Alex ; Ho, Arthur ; Parel, Jean Marie ; Manns, Fabrice. / System for on-and off-axis volumetric OCT imaging and ray tracing aberrometry of the crystalline lens. In: Biomedical Optics Express. 2018 ; Vol. 9, No. 8. pp. 3834-3851.

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abstract = "We present a new in vitro instrument for measuring shape and wavefront aberrations of the primate crystalline lens, both on-and off-axis, while simulating accommodation with a motorized lens stretching system. The instrument merges spectral domain optical coherence tomography (SD-OCT) imaging and ray tracing aberrometry using an approach that senses wavefront aberrations of the lens with the OCT probing beam. Accuracy and repeatability of aberration measurements were quantified. Preliminary experiments on two human and four cynomolgus monkey lenses demonstrate the ability of the system to measure the lens shape, spherical aberration and peripheral defocus, and their changes during simulated accommodation.",

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note = "Funding Information: National Eye Institute (R01EY021834; 1F30-EY027162; F31EY021444); Ruth L. Kirschstein National Research Service Award Individual Pre-doctoral Fellowship; BMH; P30EY14801 (Center Core Grant); the Florida Lions Eye Bank and Beauty of Sight Foundation; the Henri and Flore Lesieur Foundation (JMP); Drs. Raksha Urs and Aaron Furtado; Karl R. Olsen, MD and Martha E. Hildebrandt, PhD; an unrestricted grant from Research to Prevent Blindness; Australian Federal Government Cooperative Research Centre Scheme through the Vision Cooperative Research Centre.",

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AU - Chang, Yu Cherng

AU - Mohamed, Ashik

AU - Sravani, N. Geetha

AU - Durkee, Heather

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AU - Gonzalez, Alex

AU - Ho, Arthur

AU - Parel, Jean Marie

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