Syrian hamsters express diverse MHC class I gene products

David Watkins, Zheng W. Chen, Austin L. Hughes, Alexandra Lagos, Andrew M. Lewis, John A. Shadduck, Norman L. Letvin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

MHC class I glycoproteins are highly diverse in most species. The Syrian hamster has long been thought to express monomorphic MHC class I molecules and thus be an exception to this rule. Here we show that Syrian hamsters express diverse MHC class I gene products. The nucleotide sequences of the α-1 and α-2 domains of classical Syrian hamster MHC class I molecules are highly variable and show evidence of having been under selective pressures at their Ag recognition sites. Interestingly, none of the Syrian hamster class I genes was closely related to their counterparts in the mouse. These observations suggest that Syrian hamsters in the wild may express diverse MHC class I molecules.

Original languageEnglish
Pages (from-to)3483-3490
Number of pages8
JournalJournal of Immunology
Volume145
Issue number10
StatePublished - Nov 15 1990
Externally publishedYes

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MHC Class I Genes
Mesocricetus
Glycoproteins

ASJC Scopus subject areas

  • Immunology

Cite this

Watkins, D., Chen, Z. W., Hughes, A. L., Lagos, A., Lewis, A. M., Shadduck, J. A., & Letvin, N. L. (1990). Syrian hamsters express diverse MHC class I gene products. Journal of Immunology, 145(10), 3483-3490.

Syrian hamsters express diverse MHC class I gene products. / Watkins, David; Chen, Zheng W.; Hughes, Austin L.; Lagos, Alexandra; Lewis, Andrew M.; Shadduck, John A.; Letvin, Norman L.

In: Journal of Immunology, Vol. 145, No. 10, 15.11.1990, p. 3483-3490.

Research output: Contribution to journalArticle

Watkins, D, Chen, ZW, Hughes, AL, Lagos, A, Lewis, AM, Shadduck, JA & Letvin, NL 1990, 'Syrian hamsters express diverse MHC class I gene products', Journal of Immunology, vol. 145, no. 10, pp. 3483-3490.
Watkins D, Chen ZW, Hughes AL, Lagos A, Lewis AM, Shadduck JA et al. Syrian hamsters express diverse MHC class I gene products. Journal of Immunology. 1990 Nov 15;145(10):3483-3490.
Watkins, David ; Chen, Zheng W. ; Hughes, Austin L. ; Lagos, Alexandra ; Lewis, Andrew M. ; Shadduck, John A. ; Letvin, Norman L. / Syrian hamsters express diverse MHC class I gene products. In: Journal of Immunology. 1990 ; Vol. 145, No. 10. pp. 3483-3490.
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