Syrian hamsters express diverse MHC class I gene products

D. I. Watkins, Z. W. Chen, A. L. Hughes, A. Lagos, A. M. Lewis, J. A. Shadduck, N. L. Letvin

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

MHC class I glycoproteins are highly diverse in most species. The Syrian hamster has long been thought to express monomorphic MHC class I molecules and thus be an exception to this rule. Here we show that Syrian hamsters express diverse MHC class I gene products. The nucleotide sequences of the α-1 and α-2 domains of classical Syrian hamster MHC class I molecules are highly variable and show evidence of having been under selective pressures at their Ag recognition sites. Interestingly, none of the Syrian hamster class I genes was closely related to their counterparts in the mouse. These observations suggest that Syrian hamsters in the wild may express diverse MHC class I molecules.

Original languageEnglish (US)
Pages (from-to)3483-3490
Number of pages8
JournalJournal of Immunology
Volume145
Issue number10
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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