Abstract
We describe two human immunodeficiency virus (HIV)-infected patients with syphilitic cerebral gummas. Both patients presented with a seizure disorder associated with an isolated, peripherally located, contrast-enhancing lesion of the brain on CT. Cranial MRI performed on one patient revealed durai thickening in the region of the lesion. A brain biopsy in that patient revealed a lymphoplasmacytic infiltrate with extensive perivascular inflammation. Clinical manifestations, radiographic resolution of the lesions, and a decline in nontreponemal serologic tests for syphilis followed high-dose aqueous penicillin therapy in both patients. These patients illustrate that (1) cerebral mass lesions occurring with HIV infection may result from syphilis; (2) seizures may be the presenting manifestation of this form of neurosyphilis; and (3) high-dose, intravenous, aqueous penicillin is effective in treating these lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 1282-1287 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 42 |
| Issue number | 7 |
| State | Published - Jul 1 1992 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Syphilitic cerebral gumma with HIV infection. / Berger, J. R.; Waskin, H.; Pall, L.; Hensley, G.; Ihmedian, I.; Judith Post, M.
In: Neurology, Vol. 42, No. 7, 01.07.1992, p. 1282-1287.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Syphilitic cerebral gumma with HIV infection
AU - Berger, J. R.
AU - Waskin, H.
AU - Pall, L.
AU - Hensley, G.
AU - Ihmedian, I.
AU - Judith Post, M.
PY - 1992/7/1
Y1 - 1992/7/1
N2 - We describe two human immunodeficiency virus (HIV)-infected patients with syphilitic cerebral gummas. Both patients presented with a seizure disorder associated with an isolated, peripherally located, contrast-enhancing lesion of the brain on CT. Cranial MRI performed on one patient revealed durai thickening in the region of the lesion. A brain biopsy in that patient revealed a lymphoplasmacytic infiltrate with extensive perivascular inflammation. Clinical manifestations, radiographic resolution of the lesions, and a decline in nontreponemal serologic tests for syphilis followed high-dose aqueous penicillin therapy in both patients. These patients illustrate that (1) cerebral mass lesions occurring with HIV infection may result from syphilis; (2) seizures may be the presenting manifestation of this form of neurosyphilis; and (3) high-dose, intravenous, aqueous penicillin is effective in treating these lesions.
AB - We describe two human immunodeficiency virus (HIV)-infected patients with syphilitic cerebral gummas. Both patients presented with a seizure disorder associated with an isolated, peripherally located, contrast-enhancing lesion of the brain on CT. Cranial MRI performed on one patient revealed durai thickening in the region of the lesion. A brain biopsy in that patient revealed a lymphoplasmacytic infiltrate with extensive perivascular inflammation. Clinical manifestations, radiographic resolution of the lesions, and a decline in nontreponemal serologic tests for syphilis followed high-dose aqueous penicillin therapy in both patients. These patients illustrate that (1) cerebral mass lesions occurring with HIV infection may result from syphilis; (2) seizures may be the presenting manifestation of this form of neurosyphilis; and (3) high-dose, intravenous, aqueous penicillin is effective in treating these lesions.
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M3 - Article
C2 - 1620334
AN - SCOPUS:0026780721
VL - 42
SP - 1282
EP - 1287
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 7
ER -