Synthetic versus natural receptors: Supramolecular control of chemical sensing in fish

José P. Da Silva; Rajib Choudhury; Mintu Porel; Uwe Pischel; Steffen Jockusch; Peter C. Hubbard; Vaidhyanathan Ramamurthy; Adelino V.M. Canário

doi:10.1021/cb500172u

Synthetic versus natural receptors: Supramolecular control of chemical sensing in fish

José P. Da Silva, Rajib Choudhury, Mintu Porel, Uwe Pischel, Steffen Jockusch, Peter C. Hubbard, Vaidhyanathan Ramamurthy, Adelino V.M. Canário

Chemistry

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.

Original language	English (US)
Pages (from-to)	1432-1436
Number of pages	5
Journal	ACS Chemical Biology
Volume	9
Issue number	7
DOIs	https://doi.org/10.1021/cb500172u
State	Published - Jul 18 2014

ASJC Scopus subject areas

Biochemistry
Molecular Medicine

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10.1021/cb500172u

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Da Silva, J. P., Choudhury, R., Porel, M., Pischel, U., Jockusch, S., Hubbard, P. C., Ramamurthy, V., & Canário, A. V. M. (2014). Synthetic versus natural receptors: Supramolecular control of chemical sensing in fish. ACS Chemical Biology, 9(7), 1432-1436. https://doi.org/10.1021/cb500172u

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abstract = "The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.",

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AU - Jockusch, Steffen

AU - Hubbard, Peter C.

AU - Ramamurthy, Vaidhyanathan

AU - Canário, Adelino V.M.

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