Synthetic versus natural receptors: Supramolecular control of chemical sensing in fish

José P. Da Silva, Rajib Choudhury, Mintu Porel, Uwe Pischel, Steffen Jockusch, Peter C. Hubbard, Vaidhyanathan Ramamurthy, Adelino V.M. Canário

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.

Original languageEnglish (US)
Pages (from-to)1432-1436
Number of pages5
JournalACS Chemical Biology
Volume9
Issue number7
DOIs
StatePublished - Jul 18 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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