TY - JOUR
T1 - Synthetic versus natural receptors
T2 - Supramolecular control of chemical sensing in fish
AU - Da Silva, José P.
AU - Choudhury, Rajib
AU - Porel, Mintu
AU - Pischel, Uwe
AU - Jockusch, Steffen
AU - Hubbard, Peter C.
AU - Ramamurthy, Vaidhyanathan
AU - Canário, Adelino V.M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2014/7/18
Y1 - 2014/7/18
N2 - The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.
AB - The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.
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U2 - 10.1021/cb500172u
DO - 10.1021/cb500172u
M3 - Article
C2 - 24841288
AN - SCOPUS:84904543750
VL - 9
SP - 1432
EP - 1436
JO - ACS Chemical Biology
JF - ACS Chemical Biology
SN - 1554-8929
IS - 7
ER -