Synthetic thyrotropin-releasing hormone. Activity in men and women, specificity of action, inhibition by triiodothyronine, and activity orally

C. Y. Bowers, Andrew V Schally, A. Kastin, A. Arimura, D. S. Schalch, C. Gual, E. Castineda, K. Folkers

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In this study normal women were more sensitive to synthetic TRH than normal men although their responses were more variable. TRH mainly stimulated release of TSH but there were exceptions since an increased release of other pituitary hormones occasionally occurred. Pretreatment with T3 partially or completely inhibited the TRH response. TRH was active orally and produced prolonged elevation of serum TSH levels.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalJournal of Medicinal Chemistry
Volume14
Issue number6
StatePublished - Dec 1 1971
Externally publishedYes

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Thyrotropin-Releasing Hormone
Pituitary Hormones
Triiodothyronine
Serum

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthetic thyrotropin-releasing hormone. Activity in men and women, specificity of action, inhibition by triiodothyronine, and activity orally. / Bowers, C. Y.; Schally, Andrew V; Kastin, A.; Arimura, A.; Schalch, D. S.; Gual, C.; Castineda, E.; Folkers, K.

In: Journal of Medicinal Chemistry, Vol. 14, No. 6, 01.12.1971, p. 477-481.

Research output: Contribution to journalArticle

Bowers, C. Y. ; Schally, Andrew V ; Kastin, A. ; Arimura, A. ; Schalch, D. S. ; Gual, C. ; Castineda, E. ; Folkers, K. / Synthetic thyrotropin-releasing hormone. Activity in men and women, specificity of action, inhibition by triiodothyronine, and activity orally. In: Journal of Medicinal Chemistry. 1971 ; Vol. 14, No. 6. pp. 477-481.
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