Synthetic Thyrotropin-Releasing Hormone. Activity in Men and Women, Specificity of Action, Inhibition by Triiodothyronine, and Activity Orally†

C. Y. Bowers, A. V. Schally, A. Kastin, A. Arimura, D. S. Schalch, C. Gual, E. Castineda, K. Folkers

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

In this study normal women were more sensitive to synthetic TRH than normal men although their responses were more variable. TRH mainly stimulated release of TSH but there were exceptions since an increased release of other pituitary hormones occasionally occurred. Pretreatment with T3 partially or completely inhibited the TRH response. TRH was active orally and produced prolonged elevation of serum TSH levels.

Original languageEnglish (US)
Pages (from-to)477-481
Number of pages5
JournalJournal of Medicinal Chemistry
Volume14
Issue number6
DOIs
StatePublished - Jun 1 1971
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Synthetic Thyrotropin-Releasing Hormone. Activity in Men and Women, Specificity of Action, Inhibition by Triiodothyronine, and Activity Orally†'. Together they form a unique fingerprint.

Cite this