Synthetic meshwork implant for glaucoma filtering surgery: Effect of adjunct heparin and sodium hyaluronate in rabbits

Hiroyuki Kondo, Francisco Fantes, Hirohiko Kato, Sandrine Gautier, Jean Marie Parel

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE: To evaluate the efficacy of a novel filtering implant, a synthetic meshwork (MESH), with or without heparin or sodium hyaluronate amendment. MATERIALS AND METHODS: Eighteen eyes of 18 rabbits received MESH surgery. The eyes were divided into three subgroups. Six eyes received the MESH implant with no modification (group 1), 6 eyes received MESH saturated with heparin (group 2), and 6 eyes received MESH with sodium hyaluronate administration into the anterior chamber during surgery (group 3). Intraocular pressure (IOP) and outflow facility were measured during a period of 6 months. RESULTS: The MESH-implanted eyes showed lower IOP and higher outflow facility than control eyes up to postoperative days 119 and 49, respectively (P > .05). Earliest functional failure was seen in group 3 and latest in group 2. CONCLUSION: MESH implant surgery showed a long-term efficacy in reducing IOP. The beneficial effects of added heparin were limited. Sodium hyaluronate administration reduced the efficacy of the implant device.

Original languageEnglish (US)
Pages (from-to)669-676
Number of pages8
JournalOphthalmic Surgery and Lasers
Volume29
Issue number8
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Ophthalmology

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