Synthetic cornea

Biocompatibility and optics

Jean-Marie A Parel, Stephan Kaminski, Viviana Fernandez, Eduardo C Alfonso, Peggy Lamar, Emmanuel Lacombe, Bernard Duchesne, Sander Dubovy, Fabrice Manns, Pascal O. Rol

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Purpose. Experimentally find a method to provide a safe surgical technique and an inexpensive and long lasting mesoplant for the restoration of vision in patients with bilateral corneal blindness due to ocular surface and stromal diseases. Methods. Identify the least invasive and the safest surgical technique for synthetic cornea implantation. Identify the most compatible biomaterials and the optimal shape a synthetic cornea must have to last a long time when implanted in vivo. Results. Penetrating procedures were deemed too invasive, time consuming, difficult and prone to long term complications. Therefore a non-penetrating delamination technique with central trephination was developed to preserve the integrity of Descemet's membrane and the anterior segment. Even though this approach limits the number of indications, it is acceptable since the majority of patients only have opacities in the stroma. The prosthesis was designed to fit in the removed tissue plane with its skirt fitted under the delaminated stroma. To improve retention, the trephination wall was made conical with the smallest opening on the anterior surface and a hat-shaped mesoplant was made to fit. The skirt was perforated in its perimeter to allow passage of nutrients and tissues ingrowths. To simplify the fabrication procedure, the haptic and optic were made of the same polymer. The intrastromal biocompatibility of several hydrogels was found superior to current clinically used PMMA and PTFE materials. Monobloc mesoplants made of 4 different materials were implanted in rabbits and followed weekly until extrusion occurred. Some remained optically clear allowing for fundus photography. Conclusions. Hydrogel synthetic corneas can be made to survive for periods longer than 1 year. ArF excimer laser photoablation studies are needed to determine the refractive correction potential of these mesoplants. A pilot FDA clinical trial is needed to assess the mesoplant efficacy and very long-term stability.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsF. Manns, P.G. Soderberg, A. Ho
Pages123-128
Number of pages6
Volume4611
DOIs
StatePublished - 2002
EventOphthalmic Technologies XII - San Jose, CA, United States
Duration: Jan 19 2002Jan 20 2002

Other

OtherOphthalmic Technologies XII
CountryUnited States
CitySan Jose, CA
Period1/19/021/20/02

Fingerprint

cornea
biocompatibility
Biocompatibility
Hydrogels
skirts
Optics
optics
Tissue
Opacity
Photography
Excimer lasers
Polytetrafluoroethylenes
Delamination
Biomaterials
blindness
Nutrients
Restoration
Extrusion
photography
rabbits

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Parel, J-M. A., Kaminski, S., Fernandez, V., Alfonso, E. C., Lamar, P., Lacombe, E., ... Rol, P. O. (2002). Synthetic cornea: Biocompatibility and optics. In F. Manns, P. G. Soderberg, & A. Ho (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4611, pp. 123-128) https://doi.org/10.1117/12.470584

Synthetic cornea : Biocompatibility and optics. / Parel, Jean-Marie A; Kaminski, Stephan; Fernandez, Viviana; Alfonso, Eduardo C; Lamar, Peggy; Lacombe, Emmanuel; Duchesne, Bernard; Dubovy, Sander; Manns, Fabrice; Rol, Pascal O.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / F. Manns; P.G. Soderberg; A. Ho. Vol. 4611 2002. p. 123-128.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Parel, J-MA, Kaminski, S, Fernandez, V, Alfonso, EC, Lamar, P, Lacombe, E, Duchesne, B, Dubovy, S, Manns, F & Rol, PO 2002, Synthetic cornea: Biocompatibility and optics. in F Manns, PG Soderberg & A Ho (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4611, pp. 123-128, Ophthalmic Technologies XII, San Jose, CA, United States, 1/19/02. https://doi.org/10.1117/12.470584
Parel J-MA, Kaminski S, Fernandez V, Alfonso EC, Lamar P, Lacombe E et al. Synthetic cornea: Biocompatibility and optics. In Manns F, Soderberg PG, Ho A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4611. 2002. p. 123-128 https://doi.org/10.1117/12.470584
Parel, Jean-Marie A ; Kaminski, Stephan ; Fernandez, Viviana ; Alfonso, Eduardo C ; Lamar, Peggy ; Lacombe, Emmanuel ; Duchesne, Bernard ; Dubovy, Sander ; Manns, Fabrice ; Rol, Pascal O. / Synthetic cornea : Biocompatibility and optics. Proceedings of SPIE - The International Society for Optical Engineering. editor / F. Manns ; P.G. Soderberg ; A. Ho. Vol. 4611 2002. pp. 123-128
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