Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

M. P. Lutolf, J. A. Hubbell

Research output: Contribution to journalArticle

3145 Citations (Scopus)

Abstract

New generations of synthetic biomaterials are being developed at a rapid pace for use as three-dimensional extracellular microenvironments to mimic the regulatory characteristics of natural extracellular matrices (ECMs) and ECM-bound growth factors, both for therapeutic applications and basic biological studies. Recent advances include nanofibrillar networks formed by self-assembly of small building blocks, artificial ECM networks from protein polymers or peptide-conjugated synthetic polymers that present bioactive ligands and respond to cell-secreted signals to enable proteolytic remodeling. These materials have already found application in differentiating stem cells into neurons, repairing bone and inducing angiogenesis. Although modern synthetic biomaterials represent oversimplified mimics of natural ECMs lacking the essential natural temporal and spatial complexity, a growing symbiosis of materials engineering and cell biology may ultimately result in synthetic materials that contain the necessary signals to recapitulate developmental processes in tissue- and organ-specific differentiation and morphogenesis.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalNature Biotechnology
Volume23
Issue number1
DOIs
StatePublished - Dec 12 2005
Externally publishedYes

Fingerprint

Biocompatible Materials
Tissue Engineering
Morphogenesis
Tissue engineering
Biomaterials
Extracellular Matrix
Polymers
Cytology
Symbiosis
Extracellular Matrix Proteins
Stem cells
Self assembly
Peptides
Neurons
Cell Biology
Intercellular Signaling Peptides and Proteins
Bone
Stem Cells
Ligands
Tissue

ASJC Scopus subject areas

  • Microbiology

Cite this

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. / Lutolf, M. P.; Hubbell, J. A.

In: Nature Biotechnology, Vol. 23, No. 1, 12.12.2005, p. 47-55.

Research output: Contribution to journalArticle

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