Synthesis of C-11 iodoantipyrine for positron emission tomography

J. A. Campbell, R. D. Finn, T. E. Boothe, B. Djermouni, Myron Ginsberg, A. H. Lockwood, A. J. Gilson, H. J. Ache

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have developed a method for the synthesis of C-11 iodoantipyrine. Carbon-11-labeled methyl iodide, prepared from 11CO 2, was used to methylate 3-methyl-1-phenyl-2-pyrazolin-5-one to form C-11 antipyrine. Following silica-gel column chromatography and iodination, radiochemical purity of the C-11 iodoantipyrine was more than 99.5%, with a 10% yield and a specific activity of 30 mCi/μmol. Preliminary animal studies showed complete cerebral extraction and local cerebral blood-flow values that were within 4.6% of those obtained using C-14 iodoantipyrine. The C-11 analog, with positron emission tomography, will facilitate local cerebral blood-flow studies in human subjects.

Original languageEnglish
Pages (from-to)538-541
Number of pages4
JournalJournal of Nuclear Medicine
Volume22
Issue number6
StatePublished - Jul 20 1981
Externally publishedYes

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Cerebrovascular Circulation
Positron-Emission Tomography
Antipyrine
Halogenation
Silica Gel
Gel Chromatography
Carbon
iodoantipyrine

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Campbell, J. A., Finn, R. D., Boothe, T. E., Djermouni, B., Ginsberg, M., Lockwood, A. H., ... Ache, H. J. (1981). Synthesis of C-11 iodoantipyrine for positron emission tomography. Journal of Nuclear Medicine, 22(6), 538-541.

Synthesis of C-11 iodoantipyrine for positron emission tomography. / Campbell, J. A.; Finn, R. D.; Boothe, T. E.; Djermouni, B.; Ginsberg, Myron; Lockwood, A. H.; Gilson, A. J.; Ache, H. J.

In: Journal of Nuclear Medicine, Vol. 22, No. 6, 20.07.1981, p. 538-541.

Research output: Contribution to journalArticle

Campbell, JA, Finn, RD, Boothe, TE, Djermouni, B, Ginsberg, M, Lockwood, AH, Gilson, AJ & Ache, HJ 1981, 'Synthesis of C-11 iodoantipyrine for positron emission tomography', Journal of Nuclear Medicine, vol. 22, no. 6, pp. 538-541.
Campbell JA, Finn RD, Boothe TE, Djermouni B, Ginsberg M, Lockwood AH et al. Synthesis of C-11 iodoantipyrine for positron emission tomography. Journal of Nuclear Medicine. 1981 Jul 20;22(6):538-541.
Campbell, J. A. ; Finn, R. D. ; Boothe, T. E. ; Djermouni, B. ; Ginsberg, Myron ; Lockwood, A. H. ; Gilson, A. J. ; Ache, H. J. / Synthesis of C-11 iodoantipyrine for positron emission tomography. In: Journal of Nuclear Medicine. 1981 ; Vol. 22, No. 6. pp. 538-541.
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