Synthesis of C-11 iodoantipyrine for positron emission tomography

J. A. Campbell, R. D. Finn, T. E. Boothe, B. Djermouni, M. D. Ginsberg, A. H. Lockwood, A. J. Gilson, H. J. Ache

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We have developed a method for the synthesis of C-11 iodoantipyrine. Carbon-11-labeled methyl iodide, prepared from 11CO 2, was used to methylate 3-methyl-1-phenyl-2-pyrazolin-5-one to form C-11 antipyrine. Following silica-gel column chromatography and iodination, radiochemical purity of the C-11 iodoantipyrine was more than 99.5%, with a 10% yield and a specific activity of 30 mCi/μmol. Preliminary animal studies showed complete cerebral extraction and local cerebral blood-flow values that were within 4.6% of those obtained using C-14 iodoantipyrine. The C-11 analog, with positron emission tomography, will facilitate local cerebral blood-flow studies in human subjects.

Original languageEnglish (US)
Pages (from-to)538-541
Number of pages4
JournalJournal of Nuclear Medicine
Volume22
Issue number6
StatePublished - Jul 20 1981
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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