Synthesis of a coumarin based fluorescent amino acid

Guodong Sui, Péter Kele, Jhony Orbulescu, Qun Huo, Roger Leblanc

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

L-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid (L-Adp), as a non-proteinogenic fluorescent amino acid has been synthesized by a highly stereoselective routine (>99.5%). This fluorescent amino acid, as fluorophore-quencher pair, may be used to study peptide assays. For enantiomeric excess determination, the racemic DL-Adp (DL-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid) has also been synthesized.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalLetters in Peptide Science
Volume8
Issue number1
DOIs
StatePublished - Mar 20 2002

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Propionic acid
Amino acids
Amino Acids
Fluorophores
Peptides
Assays
propionic acid
coumarin
3,2'-difucosyllactose

Keywords

  • Coumarin
  • Fluorescence spectra
  • Fluorescent label
  • Fluorophore-quencher

ASJC Scopus subject areas

  • Biochemistry

Cite this

Synthesis of a coumarin based fluorescent amino acid. / Sui, Guodong; Kele, Péter; Orbulescu, Jhony; Huo, Qun; Leblanc, Roger.

In: Letters in Peptide Science, Vol. 8, No. 1, 20.03.2002, p. 47-51.

Research output: Contribution to journalArticle

Sui, Guodong ; Kele, Péter ; Orbulescu, Jhony ; Huo, Qun ; Leblanc, Roger. / Synthesis of a coumarin based fluorescent amino acid. In: Letters in Peptide Science. 2002 ; Vol. 8, No. 1. pp. 47-51.
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