Synthesis of a coumarin based fluorescent amino acid

Guodong Sui, Péter Kele, Jhony Orbulescu, Qun Huo, Roger M. Leblanc

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


L-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid (L-Adp), as a non-proteinogenic fluorescent amino acid has been synthesized by a highly stereoselective routine (>99.5%). This fluorescent amino acid, as fluorophore-quencher pair, may be used to study peptide assays. For enantiomeric excess determination, the racemic DL-Adp (DL-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid) has also been synthesized.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalLetters in Peptide Science
Issue number1
StatePublished - Jan 2001


  • Coumarin
  • Fluorescence spectra
  • Fluorescent label
  • Fluorophore-quencher

ASJC Scopus subject areas

  • Biochemistry


Dive into the research topics of 'Synthesis of a coumarin based fluorescent amino acid'. Together they form a unique fingerprint.

Cite this