Synthesis in living cells with the assistance of supramolecular nanocarriers

Sherif Shaban Ragab, Ek Raj Thapaliya, Yang Zhang, Sicheng Tang, Jeffrey Blye McMahan, Sheyum Syed, Burjor Captain, Francisco Raymo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Independent supramolecular nanocarriers can transport pairs of complementary reactants inside living cells in two consecutive incubation steps. After the second internalization step, the nonemissive reactants produce a fluorescent product with the concomitant appearance of intense fluorescence exclusively in the intracellular space. These results demonstrate that supramolecular delivery can be exploited to perform chemical reactions inside target cells and can lead to valuable strategies for the intracellular synthesis of drugs.

Original languageEnglish (US)
Pages (from-to)32441-32445
Number of pages5
JournalRSC Advances
Volume6
Issue number39
DOIs
StatePublished - 2016

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Chemical reactions
Fluorescence
Cells
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Ragab, S. S., Thapaliya, E. R., Zhang, Y., Tang, S., McMahan, J. B., Syed, S., ... Raymo, F. (2016). Synthesis in living cells with the assistance of supramolecular nanocarriers. RSC Advances, 6(39), 32441-32445. https://doi.org/10.1039/c6ra04335f

Synthesis in living cells with the assistance of supramolecular nanocarriers. / Ragab, Sherif Shaban; Thapaliya, Ek Raj; Zhang, Yang; Tang, Sicheng; McMahan, Jeffrey Blye; Syed, Sheyum; Captain, Burjor; Raymo, Francisco.

In: RSC Advances, Vol. 6, No. 39, 2016, p. 32441-32445.

Research output: Contribution to journalArticle

Ragab SS, Thapaliya ER, Zhang Y, Tang S, McMahan JB, Syed S et al. Synthesis in living cells with the assistance of supramolecular nanocarriers. RSC Advances. 2016;6(39):32441-32445. https://doi.org/10.1039/c6ra04335f
Ragab, Sherif Shaban ; Thapaliya, Ek Raj ; Zhang, Yang ; Tang, Sicheng ; McMahan, Jeffrey Blye ; Syed, Sheyum ; Captain, Burjor ; Raymo, Francisco. / Synthesis in living cells with the assistance of supramolecular nanocarriers. In: RSC Advances. 2016 ; Vol. 6, No. 39. pp. 32441-32445.
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