Synthesis, characterization and in vivo drug delivery study of a biodegradable nano-structured molecularly imprinted polymer based on cross-linker of fructose

Ebadullah Asadi, Majid Abdouss, Roger Leblanc, Noushin Ezzati, James N Wilson, Davood Kordestani

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

In this study, a new biodegradable cross-linker agent based on fructose was reported for fabrication of brain targeted molecularly imprinted polymer (MIP). The applied strategy for targeting drug delivery was based on two mechanisms. Firstly, the magnetic structure of prepared MIP which facilitates the aggregation of carrier near target tissue under magnetic field. Second, the tendency of brain cell to use the produced fructose during degradation of MIP as fuel. In synthesis procedure magnetic fluorescent multi core shell structure MIP was prepared via co-precipitation polymerization in the presence of olanzapine as template and fructose with double acts, as monomer and cross-linker. Various kinds of in vitro and in vivo experiments were carried out to indicate the considered properties of carrier. The obtained data confirmed the designed carrier olanzapine satisfactorily meet the requirement in brain drug delivery application.

Original languageEnglish (US)
Pages (from-to)226-237
Number of pages12
JournalPolymer
Volume97
DOIs
StatePublished - Aug 5 2016

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Keywords

  • Biodegradable
  • Controlled drug release
  • Targeting drug delivery

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

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