Synthesis, Anti-HIV, and Cytotoxic Activity of New AZT Conjugates of Steroid Acids

Zhengqing You, A. Moshin Mian, Ram P. Agarwal, Henry Joung Lee

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In an attempt to discover potent anti-HIV agents devoid of the serious toxicity of the current HIV-reverse transcriptase inhibitors, three steroid prodrugs of AZT have been synthesized and their anti-HIV profiles determined with CEM-SS cell line. Two of the prodrugs were active against HIV, though weaker than AZT. The third agent was totally inactive against HIV. However, it demonstrated remarkably high anti-growth activities. Further experiments established that growth inhibition of the third agent was caused by induction of apoptosis rather than general necrosis.

Original languageEnglish (US)
Pages (from-to)2049-2060
Number of pages12
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number11
DOIs
StatePublished - Dec 1 2003

Keywords

  • Anti-HIV
  • AZT
  • Cytotoxicity
  • Prodrug
  • Steroid

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

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