Abstract
The new L-glutaminyl-L-histidyl-L-prolinamide (Gln-His-Pro(NH2)) has been synthesized. This open glutaminyl-form has been compared with the cyclized pyro-form of (pyro)Glu-His-Pro(NH2), thyrotropin releasing hormone (TRH). Gln-His-Pro(NH2) is converted into (pyro)Glu-His-Pro(NH2) under very mild conditions some of which are analogous to steps used in the isolation of TRH. Gln-His-Pro(NH2) had up to five per cent of the activity of TRH although it is unknown whether this activity is intrinsic or due to contamination or conversion. There is no evidence that Gln-His-Pro(NH2) is present in the hypothalamus, but if it were it could be a moiety of a larger molecule which is convertible into Gln- or (pyro)Glu-His-Pro(NH2) or it could be a biosynthetic precursor or a metabolic transformation product of TRH. (Pyro)Glu-His-Pro(NH2) shows the functions expected of the hormone.
| Original language | English |
|---|---|
| Pages (from-to) | 110-113 |
| Number of pages | 4 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 8 1970 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Synthesis and relationship of L-glutaminyl-L-histidyl-L-prolinamide to the thyrotropin releasing hormone. / Folkers, Karl; Chang, Jaw Kang; Currie, Bruce L.; Bowers, C. Y.; Weil, Alice; Schally, Andrew V.
In: Biochemical and Biophysical Research Communications, Vol. 39, No. 1, 08.04.1970, p. 110-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and relationship of L-glutaminyl-L-histidyl-L-prolinamide to the thyrotropin releasing hormone
AU - Folkers, Karl
AU - Chang, Jaw Kang
AU - Currie, Bruce L.
AU - Bowers, C. Y.
AU - Weil, Alice
AU - Schally, Andrew V
PY - 1970/4/8
Y1 - 1970/4/8
N2 - The new L-glutaminyl-L-histidyl-L-prolinamide (Gln-His-Pro(NH2)) has been synthesized. This open glutaminyl-form has been compared with the cyclized pyro-form of (pyro)Glu-His-Pro(NH2), thyrotropin releasing hormone (TRH). Gln-His-Pro(NH2) is converted into (pyro)Glu-His-Pro(NH2) under very mild conditions some of which are analogous to steps used in the isolation of TRH. Gln-His-Pro(NH2) had up to five per cent of the activity of TRH although it is unknown whether this activity is intrinsic or due to contamination or conversion. There is no evidence that Gln-His-Pro(NH2) is present in the hypothalamus, but if it were it could be a moiety of a larger molecule which is convertible into Gln- or (pyro)Glu-His-Pro(NH2) or it could be a biosynthetic precursor or a metabolic transformation product of TRH. (Pyro)Glu-His-Pro(NH2) shows the functions expected of the hormone.
AB - The new L-glutaminyl-L-histidyl-L-prolinamide (Gln-His-Pro(NH2)) has been synthesized. This open glutaminyl-form has been compared with the cyclized pyro-form of (pyro)Glu-His-Pro(NH2), thyrotropin releasing hormone (TRH). Gln-His-Pro(NH2) is converted into (pyro)Glu-His-Pro(NH2) under very mild conditions some of which are analogous to steps used in the isolation of TRH. Gln-His-Pro(NH2) had up to five per cent of the activity of TRH although it is unknown whether this activity is intrinsic or due to contamination or conversion. There is no evidence that Gln-His-Pro(NH2) is present in the hypothalamus, but if it were it could be a moiety of a larger molecule which is convertible into Gln- or (pyro)Glu-His-Pro(NH2) or it could be a biosynthetic precursor or a metabolic transformation product of TRH. (Pyro)Glu-His-Pro(NH2) shows the functions expected of the hormone.
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UR - http://www.scopus.com/inward/citedby.url?scp=0014936706&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(70)90764-3
DO - 10.1016/0006-291X(70)90764-3
M3 - Article
VL - 39
SP - 110
EP - 113
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -