Synthesis and nicotinic acetylcholine receptor binding affinity of exo- and endo-2-(pyridinyloxymethyl)-7-azabicyclo[2.2.1]heptanes

J. Cheng, S. Izenwasser, D. Wade, M. L. Trudell

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A series of novel epibatidine analogues containing a pyridinyloxymethyl group at the 2-position were prepared and evaluated as ligands for the nicotinic acetylcholine receptor (nAChR). The in vitro binding affinities (Ki) of the 7-azabicyclo[2.2.1]heptane derivatives were measured relative to [3H]-(-)-cytisine in rat caudate-putamen tissue.

Original languageEnglish (US)
Pages (from-to)356-365
Number of pages10
JournalMedicinal Chemistry Research
Volume10
Issue number6
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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