A series of novel epibatidine analogues containing a pyridinyloxymethyl group at the 2-position were prepared and evaluated as ligands for the nicotinic acetylcholine receptor (nAChR). The in vitro binding affinities (Ki) of the 7-azabicyclo[2.2.1]heptane derivatives were measured relative to [3H]-(-)-cytisine in rat caudate-putamen tissue.
|Original language||English (US)|
|Number of pages||10|
|Journal||Medicinal Chemistry Research|
|State||Published - Jan 1 2001|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Organic Chemistry