Synthesis and Evaluation of a Bis(crown ether) Ionophore with a Conformationally Constrained Bridge in Ion-Selective Electrodes

Zhiren Xia, Ibrahim H A Badr, Shawn L. Plummer, Lawrence Cullen, Leonidas G Bachas

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A new bis(crown ether) ionophore containing two benzo-15-crown-5 moieties connected with each other via a conformationally constrained bridge attached to a C18-lipophilic side chain was designed and synthesized. The bridge consisted of an isophthalic acid derivative, which was selected in order to enhance potassium over sodium binding. Liquid-polymeric membrane ion-selective electrodes (ISEs) based on this ionophore were prepared using different plasticizers and mole ratios of lipophilic ionic additives. Membrane electrodes with optimum composition (using o-nitrophenyloctyl ether or bis(1-butylpentyl)adipate as plasticizer and 60 mol% lipophilic borate additive) show Nernstian responses toward potassium (57 and 58 mV/decade, respectively) over a wide concentration range with a micromolar detection limit. These ISEs exhibit enhanced potassium over sodium selectivity (KK+,Na+ pot=6×10-4). In addition, the electrodes show selectivities for potassium over Cs+ and NH4 + that are better than those of valinomycin-based ISEs.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalAnalytical Sciences
Volume14
Issue number1
StatePublished - 1998
Externally publishedYes

Fingerprint

Crown Ethers
Ionophores
Potassium
Plasticizers
Sodium
Valinomycin
Polymeric membranes
Borates
Liquid membranes
Electrodes
Ether
Derivatives
Membranes
Ion-Selective Electrodes
Chemical analysis

Keywords

  • Bis(crown ether)
  • Cation sensor
  • Ion-selective electrode
  • Lipophilic salt
  • Liquid-polymeric membrane
  • Neutral carrier

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Synthesis and Evaluation of a Bis(crown ether) Ionophore with a Conformationally Constrained Bridge in Ion-Selective Electrodes. / Xia, Zhiren; Badr, Ibrahim H A; Plummer, Shawn L.; Cullen, Lawrence; Bachas, Leonidas G.

In: Analytical Sciences, Vol. 14, No. 1, 1998, p. 169-173.

Research output: Contribution to journalArticle

Xia, Zhiren ; Badr, Ibrahim H A ; Plummer, Shawn L. ; Cullen, Lawrence ; Bachas, Leonidas G. / Synthesis and Evaluation of a Bis(crown ether) Ionophore with a Conformationally Constrained Bridge in Ion-Selective Electrodes. In: Analytical Sciences. 1998 ; Vol. 14, No. 1. pp. 169-173.
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