Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909

Leyte Winfield, Sari E Izenwasser, Dean Wade, Mark L. Trudell

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

A series of GBR 12909 analogues containing a 2,6-dioxopiperazine ring system were prepared and evaluated as ligands for the dopamine transporter. These less lipophilic analogues of GBR 12909 exhibited diminished in vitro binding affinities (Ki) at the dopamine transporter relative to GBR 12909.

Original languageEnglish
Pages (from-to)102-115
Number of pages14
JournalMedicinal Chemistry Research
Volume11
Issue number2
StatePublished - Jan 1 2002
Externally publishedYes

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Dopamine Plasma Membrane Transport Proteins
Ligands
vanoxerine

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909. / Winfield, Leyte; Izenwasser, Sari E; Wade, Dean; Trudell, Mark L.

In: Medicinal Chemistry Research, Vol. 11, No. 2, 01.01.2002, p. 102-115.

Research output: Contribution to journal › Article

Winfield, L, Izenwasser, SE, Wade, D & Trudell, ML 2002, 'Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909', Medicinal Chemistry Research, vol. 11, no. 2, pp. 102-115.
Winfield L, Izenwasser SE, Wade D, Trudell ML. Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909. Medicinal Chemistry Research. 2002 Jan 1;11(2):102-115.
Winfield, Leyte ; Izenwasser, Sari E ; Wade, Dean ; Trudell, Mark L. / Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909. In: Medicinal Chemistry Research. 2002 ; Vol. 11, No. 2. pp. 102-115.
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