Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909

Leyte Winfield; Sari Izenwasser; Dean Wade; Mark L. Trudell

Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909

Leyte Winfield, Sari Izenwasser, Dean Wade, Mark L. Trudell

Research output: Contribution to journal › Article › peer-review

Abstract

A series of GBR 12909 analogues containing a 2,6-dioxopiperazine ring system were prepared and evaluated as ligands for the dopamine transporter. These less lipophilic analogues of GBR 12909 exhibited diminished in vitro binding affinities (K_i) at the dopamine transporter relative to GBR 12909.

Original language	English (US)
Pages (from-to)	102-115
Number of pages	14
Journal	Medicinal Chemistry Research
Volume	11
Issue number	2
State	Published - Jan 1 2002
Externally published	Yes

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

Cite this

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title = "Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909",

abstract = "A series of GBR 12909 analogues containing a 2,6-dioxopiperazine ring system were prepared and evaluated as ligands for the dopamine transporter. These less lipophilic analogues of GBR 12909 exhibited diminished in vitro binding affinities (Ki) at the dopamine transporter relative to GBR 12909.",

author = "Leyte Winfield and Sari Izenwasser and Dean Wade and Trudell, {Mark L.}",

year = "2002",

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T1 - Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909

AU - Winfield, Leyte

AU - Izenwasser, Sari

AU - Wade, Dean

AU - Trudell, Mark L.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - A series of GBR 12909 analogues containing a 2,6-dioxopiperazine ring system were prepared and evaluated as ligands for the dopamine transporter. These less lipophilic analogues of GBR 12909 exhibited diminished in vitro binding affinities (Ki) at the dopamine transporter relative to GBR 12909.

AB - A series of GBR 12909 analogues containing a 2,6-dioxopiperazine ring system were prepared and evaluated as ligands for the dopamine transporter. These less lipophilic analogues of GBR 12909 exhibited diminished in vitro binding affinities (Ki) at the dopamine transporter relative to GBR 12909.

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JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

SN - 1054-2523

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ER -

Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909

Abstract

ASJC Scopus subject areas

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