Synthesis and dopamine transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909

Leyte Winfield, Sari Izenwasser, Dean Wade, Mark L. Trudell

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A series of GBR 12909 analogues containing a 2,6-dioxopiperazine ring system were prepared and evaluated as ligands for the dopamine transporter. These less lipophilic analogues of GBR 12909 exhibited diminished in vitro binding affinities (Ki) at the dopamine transporter relative to GBR 12909.

Original languageEnglish (US)
Pages (from-to)102-115
Number of pages14
JournalMedicinal Chemistry Research
Volume11
Issue number2
StatePublished - Jan 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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