Synthesis and degradation of cyclic nucleotides in the pituitary gland, ovary and testis of rats treated with d-Trp6-luteinizing hormone-releasing hormone

Marion T. Hierowski, Antonio J. Waring, Andrew V. Schally

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6 Scopus citations


The effect of administration of d-Trp6-Luteininzing Hormone-Releasing Hormone (LH-RH) on synthesis and degradation of cyclic nucleotides was studied in the rat. There were no significant changes in the rate of synthesis and degradation of cyclic AMP in the ovary, testis and pituitary gland of d-Trp6 LH-RH-treated rats as compared to controls. On the other hand, the levels of cyclic GMP and activity of guanylate cyclase were significantly higher in the ovary and testis as well as in the pituitary gland of animals which received the analog. The rate of hydrolysis of cyclic GMP was unchanged by the administration of d-Trp6-LH=RH. Interestingly, the cyclic CMP phosphodiesterase seemed to be activated in animals treated with d-Trp6-LH-RH.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalBBA - General Subjects
Issue number2
StatePublished - Jul 3 1981



  • (Rat endocrine
  • cyclic GMP level
  • Cyclic nucleotide turnover
  • Luteinizing hormone-releasing factor
  • Phosphosdiesterase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Medicine(all)

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