Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles

Hong Shu, Sari Izenwasser, Dean Wade, Edwin D. Stevens, Mark L. Trudell

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A series of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles were synthesized regioselectively using click chemistry and evaluated at CB1 cannabinoid receptors. The n-propyl ester 11 (Ki = 4.6 nM) and phenyl ester 14 (Ki = 11 nM) exhibited the most potent affinity of the series.

Original languageEnglish (US)
Pages (from-to)891-893
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number3
DOIs
StatePublished - Feb 1 2009

Keywords

  • Cannabinoid receptors
  • Click chemistry
  • Triazoles

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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