Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles

Hong Shu, Sari E Izenwasser, Dean Wade, Edwin D. Stevens, Mark L. Trudell

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A series of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles were synthesized regioselectively using click chemistry and evaluated at CB1 cannabinoid receptors. The n-propyl ester 11 (Ki = 4.6 nM) and phenyl ester 14 (Ki = 11 nM) exhibited the most potent affinity of the series.

Original languageEnglish
Pages (from-to)891-893
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number3
DOIs
StatePublished - Feb 1 2009

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Cannabinoid Receptor CB1
Triazoles
Esters
Click Chemistry

Keywords

  • Cannabinoid receptors
  • Click chemistry
  • Triazoles

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles. / Shu, Hong; Izenwasser, Sari E; Wade, Dean; Stevens, Edwin D.; Trudell, Mark L.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 3, 01.02.2009, p. 891-893.

Research output: Contribution to journalArticle

Shu, Hong ; Izenwasser, Sari E ; Wade, Dean ; Stevens, Edwin D. ; Trudell, Mark L. / Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 3. pp. 891-893.
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