Abstract
The luteinizing hormone-releasing hormone (LH-RH) analog, <Glu-Pyr(1)Ala-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, and the thyrotropin-releasing hormone (TRH) analog, <Glu-Pyr(1)Ala-Pro-NH2, were synthesized by azide couplings of the dipeptide hydrazide, <Glu-Pyr(1)Ala-NHNH2, to the C-terminal octapeptide of LH-RH and to proline amide, respectively. In an ovariectomized, steroid-blocked rat assay, the LH-RH analog was found to have only 1% of the LH-releasing activity of the natural hormone. The TRH analog was 1.5 times more effective than TRH itself in releasing TSH in vivo from the anterior pituitary of mice. This peptide is one of two synthetic peptides so far discovered which are more potent than TRH.
Original language | English (US) |
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Pages (from-to) | 948-949 |
Number of pages | 2 |
Journal | Journal of Medicinal Chemistry |
Volume | 18 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery