Synthesis and biological properties of [Leu-6]-LH-RH and [D-leu-6,desGly-NH210]-LH-RH ethylamide

Jesus A. Vilchez-Martinez, David H. Coy, Akira Arimura, Esther J. Coy, Yoshihiro Hirotsu, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


[Leu6,desGly-NH2 10]-LH-RH ethylamide and [Leu6]-LH-RH, two analogs of LH-RH, were prepared by the solid phase method. LH- and FSH-releasing activity of these peptides was assayed against LH-RH by subcutaneous administration in immature male rats. When the integrated levels of LH and FSH over a 6 hr period after the injection were used as parameter of the LH- and FSH-releasing activities, the [Leu6]-LH-RH showed LH-releasing activity of 9 times and FSH-releasing activity of 5 times greater than that of LH-RH. [Leu6,desGly-NH2 10]-LH-RH ethylamide showed LH- and FSH-releasing activities of 53.6 and 14.5 times greater, respectively, than that of LH-RH.

Original languageEnglish (US)
Pages (from-to)1226-1232
Number of pages7
JournalBiochemical and biophysical research communications
Issue number4
StatePublished - Aug 19 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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