Abstract
A nonapeptide analog of luteinizing hormone-releasing hormone (LH-RH), [D-Ala6, des-Gly-NH2 10]-LH-RH ethylamide, was prepared by solid-phase methodology. The peptide was assayed against LH-RH in two in vivo systems and was found to be many times more potent than the naturally occurring hormone. In one of the tests, based on elevation of LH and FSH levels after infusion into immature male rats, the analog showed LH-releasing activity of 1600% and FSH-releasing activity of 1200% compared to LH-RH.
| Original language | English |
|---|---|
| Pages (from-to) | 335-340 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 57 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 25 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Synthesis and biological properties of [D-Ala-6, des-Gly-NH2-10]-LH-RH ethylamide, a peptide with greatly enhanced LH- and FSH-releasing activity. / Coy, David H.; Coy, Esther J.; Schally, Andrew V; Vilchez-Martinez, Jesus; Hirotsu, Yoshihiro; Arimura, Akira.
In: Biochemical and Biophysical Research Communications, Vol. 57, No. 2, 25.03.1974, p. 335-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and biological properties of [D-Ala-6, des-Gly-NH2-10]-LH-RH ethylamide, a peptide with greatly enhanced LH- and FSH-releasing activity
AU - Coy, David H.
AU - Coy, Esther J.
AU - Schally, Andrew V
AU - Vilchez-Martinez, Jesus
AU - Hirotsu, Yoshihiro
AU - Arimura, Akira
PY - 1974/3/25
Y1 - 1974/3/25
N2 - A nonapeptide analog of luteinizing hormone-releasing hormone (LH-RH), [D-Ala6, des-Gly-NH2 10]-LH-RH ethylamide, was prepared by solid-phase methodology. The peptide was assayed against LH-RH in two in vivo systems and was found to be many times more potent than the naturally occurring hormone. In one of the tests, based on elevation of LH and FSH levels after infusion into immature male rats, the analog showed LH-releasing activity of 1600% and FSH-releasing activity of 1200% compared to LH-RH.
AB - A nonapeptide analog of luteinizing hormone-releasing hormone (LH-RH), [D-Ala6, des-Gly-NH2 10]-LH-RH ethylamide, was prepared by solid-phase methodology. The peptide was assayed against LH-RH in two in vivo systems and was found to be many times more potent than the naturally occurring hormone. In one of the tests, based on elevation of LH and FSH levels after infusion into immature male rats, the analog showed LH-releasing activity of 1600% and FSH-releasing activity of 1200% compared to LH-RH.
UR - http://www.scopus.com/inward/record.url?scp=0015978820&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015978820&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(74)90934-6
DO - 10.1016/0006-291X(74)90934-6
M3 - Article
C2 - 4597827
AN - SCOPUS:0015978820
VL - 57
SP - 335
EP - 340
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -