Synthesis and biological evaluation of 4-alanine-luteinizing hormone-releasing hormone ([Ala4] LH-RH)

R. Geiger, H. Wissmann, W. König, J. Sandow, Andrew V. Schally, T. W. Redding, L. Debeljuk, A. Arimura

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Synthesis of [Ala4] LH-RH as well as its chemical, physical and biological properties are described. This analogue exhibits only 5% of the activity of LH-RH decapeptide. This demonstrates that the hydroxyl group of serine4 is not absolutely essential for LH-RH activity. Although serine may be one of the groups necessary for a strong combined functional effect, it is more likely that its role is concerned with binding to the receptors.

Original languageEnglish (US)
Pages (from-to)1467-1473
Number of pages7
JournalBiochemical and biophysical research communications
Issue number6
StatePublished - Dec 18 1972


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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