Synthesis of [Ala4] LH-RH as well as its chemical, physical and biological properties are described. This analogue exhibits only 5% of the activity of LH-RH decapeptide. This demonstrates that the hydroxyl group of serine4 is not absolutely essential for LH-RH activity. Although serine may be one of the groups necessary for a strong combined functional effect, it is more likely that its role is concerned with binding to the receptors.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and biophysical research communications|
|State||Published - Dec 18 1972|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology