(Formyl-sarcosine) 1-LH-RH (I), (acetyl-sarcosine) 1-LH-RH (II), (2-pyrrolidone-4-carboxylic acid) 1-LH-RH (III), (N-methyl-2-pyrrolidone-4-carboxylic acid) 1-LH-RH (IV), hydroxyproline 1-LH-RH (V) and (cyclopentane-carboxylic acid) 1-LH-RH (VI) were synthesized by solid phase methods on a benzhydrylamine resin support. Peptides I-IV were assayed for LH- and FSH-releasing activity over a 4-h period after subcutaneous injection into immature male rats in order to detect any prolongation of activity. The peptides were found to have the following integrated LH-releasing activities compared with LH-RH: I, 64%; II, 72%; III, 19%; IV, 58%. None of the peptides were found to be longer acting than LH-RH. Peptides V and VI were far less active, 0.001% and 1.4%, respectively.
|Original language||English (US)|
|Number of pages||6|
|Journal||International journal of peptide and protein research|
|State||Published - Jan 1977|
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