Abstract
A cyclic pseudohexapeptide analog of somatostatin, cyclo(Pro[CH2S]Phe-D- Trp-Lys-Thr-Phe) was synthesized by solid phase methods and diphenylphosphoryl azide ring closure. The resulting crystalline compound possessed 23% of the growth hormone inhibitory activity of the parent tetradecapeptide and approximately 6% of the activity of the all-amide cyclic hexapeptide analog inspite of the absence of one of the two postulated intramolecular hydrogen bonds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 840-845 |
| Number of pages | 6 |
| Journal | Biochemical and biophysical research communications |
| Volume | 120 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 16 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Gero, T. W., Spatola, A. F., Torres-Aleman, I., & Schally, A. V. (1984). Synthesis and biological activity of a cyclic pseudohexapeptide analog of somatostatin. Biochemical and biophysical research communications, 120(3), 840-845. https://doi.org/10.1016/S0006-291X(84)80183-7