Abstract
A cyclic pseudohexapeptide analog of somatostatin, cyclo(Pro[CH2S]Phe-D- Trp-Lys-Thr-Phe) was synthesized by solid phase methods and diphenylphosphoryl azide ring closure. The resulting crystalline compound possessed 23% of the growth hormone inhibitory activity of the parent tetradecapeptide and approximately 6% of the activity of the all-amide cyclic hexapeptide analog inspite of the absence of one of the two postulated intramolecular hydrogen bonds.
| Original language | English |
|---|---|
| Pages (from-to) | 840-845 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 120 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 16 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Synthesis and biological activity of a cyclic pseudohexapeptide analog of somatostatin. / Gero, Thomas W.; Spatola, Arno F.; Torres-Aleman, Ignacio; Schally, Andrew V.
In: Biochemical and Biophysical Research Communications, Vol. 120, No. 3, 16.05.1984, p. 840-845.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and biological activity of a cyclic pseudohexapeptide analog of somatostatin
AU - Gero, Thomas W.
AU - Spatola, Arno F.
AU - Torres-Aleman, Ignacio
AU - Schally, Andrew V
PY - 1984/5/16
Y1 - 1984/5/16
N2 - A cyclic pseudohexapeptide analog of somatostatin, cyclo(Pro[CH2S]Phe-D- Trp-Lys-Thr-Phe) was synthesized by solid phase methods and diphenylphosphoryl azide ring closure. The resulting crystalline compound possessed 23% of the growth hormone inhibitory activity of the parent tetradecapeptide and approximately 6% of the activity of the all-amide cyclic hexapeptide analog inspite of the absence of one of the two postulated intramolecular hydrogen bonds.
AB - A cyclic pseudohexapeptide analog of somatostatin, cyclo(Pro[CH2S]Phe-D- Trp-Lys-Thr-Phe) was synthesized by solid phase methods and diphenylphosphoryl azide ring closure. The resulting crystalline compound possessed 23% of the growth hormone inhibitory activity of the parent tetradecapeptide and approximately 6% of the activity of the all-amide cyclic hexapeptide analog inspite of the absence of one of the two postulated intramolecular hydrogen bonds.
UR - http://www.scopus.com/inward/record.url?scp=0021247831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021247831&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(84)80183-7
DO - 10.1016/S0006-291X(84)80183-7
M3 - Article
C2 - 6145411
AN - SCOPUS:0021247831
VL - 120
SP - 840
EP - 845
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -