Synthesis and biological activity of a cyclic pseudohexapeptide analog of somatostatin

Thomas W. Gero, Arno F. Spatola, Ignacio Torres-Aleman, Andrew V. Schally

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A cyclic pseudohexapeptide analog of somatostatin, cyclo(Pro[CH2S]Phe-D- Trp-Lys-Thr-Phe) was synthesized by solid phase methods and diphenylphosphoryl azide ring closure. The resulting crystalline compound possessed 23% of the growth hormone inhibitory activity of the parent tetradecapeptide and approximately 6% of the activity of the all-amide cyclic hexapeptide analog inspite of the absence of one of the two postulated intramolecular hydrogen bonds.

Original languageEnglish (US)
Pages (from-to)840-845
Number of pages6
JournalBiochemical and biophysical research communications
Volume120
Issue number3
DOIs
StatePublished - May 16 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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