A cyclic pseudohexapeptide analog of somatostatin, cyclo(Pro[CH2S]Phe-D- Trp-Lys-Thr-Phe) was synthesized by solid phase methods and diphenylphosphoryl azide ring closure. The resulting crystalline compound possessed 23% of the growth hormone inhibitory activity of the parent tetradecapeptide and approximately 6% of the activity of the all-amide cyclic hexapeptide analog inspite of the absence of one of the two postulated intramolecular hydrogen bonds.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and biophysical research communications|
|State||Published - May 16 1984|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology