Syntheses and LH- and FSH-RH activities of LH-RH analogs substituted at position 8

N. Yanaihara, C. Yanaihara, T. Hashimoto, Y. Kenmochi, T. Kaneko, H. Oka, S. Saito, A. V. Schally, A. Arimura

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Syntheses by the conventional method are described of [Gln8]-LH-RH, [Leu8]-LH-RH and [Pro8] [Arg9]-LH-RH. These peptides were purified by column chromatography on CM-Sephadex and gelfiltration on Sephadex G-25 and proved to be homogeneous. The LH-RH and FSH-RH activities of these peptides were compared with those of natural LH-RH in vivo and in vitro. [Gln8]-LH-RH had significant LH- and FSH-RH activities, while [Leu8]-LH-RH and [Pro8] [Arg9]-LH-RH had lower activities.

Original languageEnglish (US)
Pages (from-to)1280-1291
Number of pages12
JournalBiochemical and biophysical research communications
Volume49
Issue number5
DOIs
StatePublished - Dec 4 1972
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Syntheses and LH- and FSH-RH activities of LH-RH analogs substituted at position 8'. Together they form a unique fingerprint.

Cite this