Syntheses and biological activities of analogs of luteinizing hormone-releasing hormone (LH-RH) substituted in position 1 or 2

N. Yanaihara, K. Tsuji, C. Yanaihara, T. Hashimoto, T. Kaneko, H. Oka, A. Arimura, A. V. Schally

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Abstract

Syntheses are described of [Pro1]-LH-RH, [Orotic acid1]-LH-RH, [Glu1]-LH-RH, [Ser2]-LH-RH, [Leu2]-LH-RH, [Gln2]-LH-RH and [Phe2]-LH-RH. The LH-releasing hormone (LH-RH) activity of each of these peptides was compared with that of natural LH-RH in vivo. [Glu1]-LH-RH and [Phe2]-LH-RH had significant LH-RH activity, while all the other analogs possessed extremely low activities. These findings are briefly discussed in the light of the structure-activity relationship for LH-RH.

Original languageEnglish (US)
Pages (from-to)165-173
Number of pages9
JournalBiochemical and biophysical research communications
Volume51
Issue number1
DOIs
StatePublished - Mar 5 1973
Externally publishedYes

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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