Syntheses and biological activities of analogs of luteinizing hormone-releasing hormone (LH-RH) substituted in position 1 or 2

N. Yanaihara, K. Tsuji, C. Yanaihara, T. Hashimoto, T. Kaneko, H. Oka, A. Arimura, Andrew V Schally

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Abstract

Syntheses are described of [Pro1]-LH-RH, [Orotic acid1]-LH-RH, [Glu1]-LH-RH, [Ser2]-LH-RH, [Leu2]-LH-RH, [Gln2]-LH-RH and [Phe2]-LH-RH. The LH-releasing hormone (LH-RH) activity of each of these peptides was compared with that of natural LH-RH in vivo. [Glu1]-LH-RH and [Phe2]-LH-RH had significant LH-RH activity, while all the other analogs possessed extremely low activities. These findings are briefly discussed in the light of the structure-activity relationship for LH-RH.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume51
Issue number1
DOIs
StatePublished - Mar 5 1973
Externally publishedYes

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Bioactivity
Gonadotropin-Releasing Hormone
Structure-Activity Relationship

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Syntheses and biological activities of analogs of luteinizing hormone-releasing hormone (LH-RH) substituted in position 1 or 2. / Yanaihara, N.; Tsuji, K.; Yanaihara, C.; Hashimoto, T.; Kaneko, T.; Oka, H.; Arimura, A.; Schally, Andrew V.

In: Biochemical and Biophysical Research Communications, Vol. 51, No. 1, 05.03.1973, p. 165-173.

Research output: Contribution to journalArticle

Yanaihara, N. ; Tsuji, K. ; Yanaihara, C. ; Hashimoto, T. ; Kaneko, T. ; Oka, H. ; Arimura, A. ; Schally, Andrew V. / Syntheses and biological activities of analogs of luteinizing hormone-releasing hormone (LH-RH) substituted in position 1 or 2. In: Biochemical and Biophysical Research Communications. 1973 ; Vol. 51, No. 1. pp. 165-173.
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AU - Hashimoto, T.

AU - Kaneko, T.

AU - Oka, H.

AU - Arimura, A.

AU - Schally, Andrew V

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